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Trial halted for bleeding reduction with abelacimab vs. rivaroxaban in AFib
“ZALEA-TIMI 71 represents a landmark study confirming the promise of Factor XI inhibition as causing substantially less bleeding than a current...
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SGLT2 inhibitors: No benefit or harm in hospitalized COVID-19
“I think the most important take-home message here is that the use of these medications appears to be safe even in really acutely ill hospitalized...
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New ESC ACS guideline combines STEMI and NSTE-ACS
“After the initial triage and management decisions, then most of the rest of the care follows a common pathway so it would make sense to consider...
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No benefit of anti-inflammatory strategy in acute myocarditis
Interleukin-1 receptor antagonist anakinra appeared safe but did not reduce complications of acute myocarditis in the ARAMIS trial.
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Aspirin still needed in first month after PCI: STOPDAPT-3
“While these absolute event rates are extremely low, they are unquestionably higher in the nonaspirin group.”
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Dietary nitrates reduce contrast-induced nephropathy in ACS
“Currently, aside from intravenous hydration, there is no proven treatment that reduces contrast-induced nephropathy. We feel that dietary...
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IV iron shows only modest benefit in HF: HEART-FID
It was hoped that the study would confirm benefits suggested in previous smaller studies, but its modest results seem to have caused more...
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Anticoagulation no benefit in presumed AFib detected by cardiac devices
“Based on the result of this trial, these occasional atrial high-rate episodes do not appear to be associated with stroke. It appears quite benign...
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Acoramidis shows encouraging results in ATTR cardiomyopathy
“ATTRibute-CM was a robustly positive trial, showing benefits across the board for acoramidis, and suggest the tantalizing possibility of genuine...
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New ESH hypertension guidelines aim for simplified message
A new feature of the guidelines is the upgrading of beta-blockers in the treatment algorithms.
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‘Striking’ benefit of lipid lowering in primary prevention
“If patients can’t tolerate a statin, then treat them with bempedoic acid. The bottom line is that these patients just need to be treated.”
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Low-dose colchicine approved for CVD: Now what?
“If we think patients are still at high risk of recurrent cardiovascular events, we have to think what we will do next. This is where this drug...
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FDA OKs low-dose colchicine for broad CV indication
“The FDA approval of colchicine for patients with atherosclerotic disease is a huge signal that physicians need to be aware of inflammation as a...
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Upping CO2 does not benefit OHCA patients: TAME
“These out-of-hospital cardiac arrest patients are a very diverse group, and it may be possible that some patients could have benefited from...
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Support for minimally invasive mitral valve repair: Mini Mitral published
“Mini-thoracotomy may appeal to patients because the procedure is less disfiguring than sternotomy. The early (6-week) benefit, albeit small and...