- Early or delayed menopause and a history of irregular menstrual cycles were significantly associated with a greater risk of new-onset atrial fibrillation (AF) in women.
- Women with nulliparity and multiparity had a greater risk of new-onset AF compared with those with one to two live births.
Why this matters
- Findings highlight the significance of considering the reproductive history of women while developing tailored screening and prevention strategies for AF.
- A population-based cohort study of 235,191 women (age, 40-69 years) without AF and a history of hysterectomy and/or bilateral oophorectomy, identified from the UK Biobank (2006-2010).
- Funding: Gender and Prevention Grant from ZonMw and other.
- During a median follow-up of 11.6 years, 4,629 (2.0%) women were diagnosed with new-onset AF.
- A history of irregular menstrual cycle was associated with higher risk of new-onset AF (adjusted HR, 1.34; 95% confidence interval, 1.01-1.79; P = .04).
- Compared with women who experienced menarche at the age of 12 years, the risk of new-onset AF was significantly higher in those who experienced menarche:
- –Earlier between the ages of 7 and 11 years (aHR, 1.10; 95% CI, 1.00-1.21; P = .04) and
- –Later between the ages of 13 and 18 years (aHR, 1.08; 95% CI, 1.00-1.17; P = .05).
- The risk of new-onset AF was significantly higher in women who experienced menopause:
- –At the age of < 35 years (aHR, 2.25; 95% CI, 1.48-3.43; P < .001);
- –Between the ages of 35 and 44 years (aHR, 1.24; 95% CI, 1.10-1.39; P < .001); and
- –At the age of ≥ 60 years (aHR, 1.34; 95% CI, 1.10-1.78; P = .04).
- Women with no live births (aHR, 1.13; 95% CI, 1.04-1.24; P < .01), four to six live births (aHR, 1.12; 95% CI, 1.01-1.24; P = .04), and ≥ seven live births (aHR, 1.67; 95% CI, 1.03-2.70; P = .03) vs. those with one to two live births had a significantly higher risk of new-onset AF.
- Observational design.
A version of this article first appeared on.
Lu Z, Aribas E, Geurts S, Roeters van Lennep JE, Ikram MA, Bos MM, de Groot NMS, Kavousi M. Association Between Sex-Specific Risk Factors and Risk of New-Onset Atrial Fibrillation Among Women. JAMA Netw Open. 2022;5(9):e2229716. doi: 10.1001/jamanetworkopen.2022.29716. PMID: 36048441.