Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Drug doses for heart failure could possibly be halved for women

Key clinical point: Women with heart failure with reduced ejection fraction may need only half the recommended doses of common drugs.

Major finding: Women reached the highest level of drug efficacy at half the doses of ACE inhibitors or angiotensin-receptor blockers and beta-blockers needed by men to reach the same level.

Study details: An ad hoc analysis of a prospective study of 1,308 men and 402 women with heart failure with reduced ejection fraction in 11 European countries.

Disclosures: The European Commission funded the study. Several study authors reported various disclosures.


Santema BT et al. Lancet. 2019 Aug 22. doi: 10.1016/S0140-6736(19)31792-1.