Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Obesity phenotyping matches patients with more effective interventions

Key clinical point: Obesity phenotyping matched patients to a more effective, personalized weight-loss drug intervention.

Major finding: The rate of greater than 10% weight loss after 1 year was 79% with phenotype-guided treatment and 35% without.

Study details: A single-center, prospective, randomized study.

Disclosures: The study received no commercial funding. Dr. Acosta is a consultant to Rhythm Pharmaceuticals and General Mills and has received research support from Novo Nordisk, Rhythm Pharmaceuticals, Satiogen, and Vivus. Dr. Clark had no disclosures.


Acosta AJ. Obesity Week 2020.