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FORT LAUDERDALE, FLA. — Symmetrical bilateral progression of knee osteoarthritis was a surprising result of a genetic study of hand osteoarthritis patients and their relatives.
“The most surprising [finding] was that progression occurred in a similar manner on both sides. This indicates to me that there is probably a strong genetic factor for progression,” Dr. Virginia Byers Kraus said in an interview during a poster session at the World Congress on Osteoarthritis, Osteoarthritis Research Society International.
Dr. Byers Kraus and associates studied 1,333 hand osteoarthritis patients for a median of 3.8 years. Participants whose osteoarthritis progressed in the medial compartment of one knee were significantly more likely to progress in the medial compartment of the other. The same held true for lateral compartment progressions.
“If you see these individuals [with hand OA], if they have an affected knee, the other is likely to be affected with osteoarthritis and they are likely to progress in parallel,” said Dr. Byers Kraus, an internist in the division of rheumatology, Duke University Medical Center, Durham, N.C. “It's a probable prognostic factor for patients.”
The cohort came from the Genetics of Generalized Osteoarthritis (GOGO) study. A total of 79% were women and the mean age was 69 years. Researchers scored baseline and follow-up radiographs for changes in Kellgren-Lawrence grade, minimal joint space, presence of osteophytes, and joint space narrowing of the medial and lateral knee compartments. They also assessed at least two affected siblings with three-joint bilateral bony enlargements in their hands to assess any genetic correlations.
“We found in a cohort with hand osteoarthritis they were more likely to have osteoarthritis [in other joints] if family members have hand osteoarthritis,” Dr. Byers Kraus said. “When you have a patient with hand osteoarthritis and relatives with hand osteoarthritis, there is an increased likelihood of bilateral knee osteoarthritis.”
The results may also have research implications. In studies of OA patients who don't progress, it's hard to assess the efficacy of a treatment. “This was responsible for the failure of a major trial on Actonel,” said Dr. Byers Kraus. “Age, female gender, obesity—outside of these, we are not good at identifying definite progressors.”
FORT LAUDERDALE, FLA. — Symmetrical bilateral progression of knee osteoarthritis was a surprising result of a genetic study of hand osteoarthritis patients and their relatives.
“The most surprising [finding] was that progression occurred in a similar manner on both sides. This indicates to me that there is probably a strong genetic factor for progression,” Dr. Virginia Byers Kraus said in an interview during a poster session at the World Congress on Osteoarthritis, Osteoarthritis Research Society International.
Dr. Byers Kraus and associates studied 1,333 hand osteoarthritis patients for a median of 3.8 years. Participants whose osteoarthritis progressed in the medial compartment of one knee were significantly more likely to progress in the medial compartment of the other. The same held true for lateral compartment progressions.
“If you see these individuals [with hand OA], if they have an affected knee, the other is likely to be affected with osteoarthritis and they are likely to progress in parallel,” said Dr. Byers Kraus, an internist in the division of rheumatology, Duke University Medical Center, Durham, N.C. “It's a probable prognostic factor for patients.”
The cohort came from the Genetics of Generalized Osteoarthritis (GOGO) study. A total of 79% were women and the mean age was 69 years. Researchers scored baseline and follow-up radiographs for changes in Kellgren-Lawrence grade, minimal joint space, presence of osteophytes, and joint space narrowing of the medial and lateral knee compartments. They also assessed at least two affected siblings with three-joint bilateral bony enlargements in their hands to assess any genetic correlations.
“We found in a cohort with hand osteoarthritis they were more likely to have osteoarthritis [in other joints] if family members have hand osteoarthritis,” Dr. Byers Kraus said. “When you have a patient with hand osteoarthritis and relatives with hand osteoarthritis, there is an increased likelihood of bilateral knee osteoarthritis.”
The results may also have research implications. In studies of OA patients who don't progress, it's hard to assess the efficacy of a treatment. “This was responsible for the failure of a major trial on Actonel,” said Dr. Byers Kraus. “Age, female gender, obesity—outside of these, we are not good at identifying definite progressors.”
FORT LAUDERDALE, FLA. — Symmetrical bilateral progression of knee osteoarthritis was a surprising result of a genetic study of hand osteoarthritis patients and their relatives.
“The most surprising [finding] was that progression occurred in a similar manner on both sides. This indicates to me that there is probably a strong genetic factor for progression,” Dr. Virginia Byers Kraus said in an interview during a poster session at the World Congress on Osteoarthritis, Osteoarthritis Research Society International.
Dr. Byers Kraus and associates studied 1,333 hand osteoarthritis patients for a median of 3.8 years. Participants whose osteoarthritis progressed in the medial compartment of one knee were significantly more likely to progress in the medial compartment of the other. The same held true for lateral compartment progressions.
“If you see these individuals [with hand OA], if they have an affected knee, the other is likely to be affected with osteoarthritis and they are likely to progress in parallel,” said Dr. Byers Kraus, an internist in the division of rheumatology, Duke University Medical Center, Durham, N.C. “It's a probable prognostic factor for patients.”
The cohort came from the Genetics of Generalized Osteoarthritis (GOGO) study. A total of 79% were women and the mean age was 69 years. Researchers scored baseline and follow-up radiographs for changes in Kellgren-Lawrence grade, minimal joint space, presence of osteophytes, and joint space narrowing of the medial and lateral knee compartments. They also assessed at least two affected siblings with three-joint bilateral bony enlargements in their hands to assess any genetic correlations.
“We found in a cohort with hand osteoarthritis they were more likely to have osteoarthritis [in other joints] if family members have hand osteoarthritis,” Dr. Byers Kraus said. “When you have a patient with hand osteoarthritis and relatives with hand osteoarthritis, there is an increased likelihood of bilateral knee osteoarthritis.”
The results may also have research implications. In studies of OA patients who don't progress, it's hard to assess the efficacy of a treatment. “This was responsible for the failure of a major trial on Actonel,” said Dr. Byers Kraus. “Age, female gender, obesity—outside of these, we are not good at identifying definite progressors.”