Dermpath Diagnosis

Angiolymphoid Hyperplasia With Eosinophilia

Angiolymphoid hyperplasia with eosinophilia (ALHE) presents as an increase in immature, primarily lymphatic vessels with plump endothelial cells lining vascular spaces, often with an associated medium-sized vessel. Surrounding the vascular component is a mixed infiltrate composed of lymphocytes that may form lymphoid follicles as well as histiocytes, plasma cells, and eosinophils. Angiolymphoid hyperplasia with eosinophilia may involve the dermis and/or subcutaneous tissue, and it often occurs in young adults, typically in the head and neck region, especially on or around the ear.


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