Clinical Edge

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Guidelines of Care for Management of Cutaneous SCC

J Am Acad Dermatol; ePub 2018 Jan 10; Alam, et al

Cutaneous squamous cell carcinoma (cSCC) is the second most common form of human cancer and has an increasing annual incidence in the US. Although most cSCC is cured with office-based therapy, advanced cSCC poses a significant risk for morbidity, impact on quality of life, and death. This outline provides evidence-based recommendations for the management of patients with cSCC. Topics addressed include:

  • biopsy techniques and histopathologic assessment,
  • tumor staging,
  • surgical and nonsurgical management,
  • follow-up and prevention of recurrence, and
  • management of advanced disease.

The primary focus of these recommendations is on evaluation and management of primary cSCC and localized disease, but where relevant, applicability to recurrent cSCC is noted, as is general information on the management of patients with metastatic disease.


Alam M, Armstrong A, Baum C, et al. Guidelines of care for the management of cutaneous squamous cell carcinoma. [Published online ahead of print January 10, 2018]. J Am Acad Dermatol. doi:10.1016/j.jaad.2017.10.007.