Clinical Inquiries

What are the risks and benefits of elective induction for uncomplicated term pregnancies?

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References

EVIDENCE-BASED ANSWER

Elective induction of labor for term, singleton, uncomplicated pregnancies appears safe for both the mother and infant (strength of recommendation [SOR]: B). The benefit of elective induction for nonmedical reasons is unclear (SOR: B).

CLINICAL COMMENTARY

Elective inductions can add costs and legal risks
Jon O. Neher, MD
Valley Medical Center, Renton, Wash

Family physicians cherish having long, collaborative relationships with patients. But when they practice obstetrics, this desire can result in feeling pressured to grant requests by pregnant patients for elective inductions. As indicated in this Clinical Inquiry, elective inductions may be relatively safe in some situations, but they always incur added costs. The cost of cervical ripening, extra monitoring, and medications to promote uterine contractions fall to the medical system. There also may be added legal risk to the provider. Eventually, some elective induction will have a bad outcome and there will be no way to defend the decision to induce as medically necessary.

Evidence summary

Induction of labor is a viable therapeutic option when the benefits of timely delivery outweigh the risks of unnecessary cesarean section or prematurity. Two large retrospective studies support the concept that cesarean section rates and admissions to neonatal intensive care units are higher with elective induction as opposed to expectant management (TABLE).1,2 A large population-based study suggests that the higher cesarean section rates in elective induction is present only among nulliparous women; in multiparous women, the rate is the same as expectant management.3 Contrasting these results are those of a large systematic review, which found lower cesarean section rates in electively induced women. Two more recent studies, a retrospective cohort study4 and a randomized controlled trial,5 found a much lower incidence of cesarean section and operative vaginal deliveries among induced vs expectantly managed women at term.

TABLE
Summary of evidence regarding induction of labor

STUDYMETHODSCESAREAN DELIVERY RATEOPERATIVE VAGINAL DELIVERYPERINATAL COMPLICATIONS
Cammu, 20021Matched cohort study. 7683 women in IND group, 7683 women in EM group. 38–410/7 weeks gestation.9.9% vs 6.5% (P=.001); NNH=30.31.67% vs 29.1% (P=.001); NNH=39.NICU admission 10.7% vs 9.4% (RR=1.03<1.14<1.25; P=.001).
Boulvain, 20012Retrospective cohort study.7430 women between 38 and 40 6/7weeks.531women in induced group vs 3353 women in spontaneous labor group.Induction of labor was found to be associated with higher risk of cesarean delivery (7.7% to 3.6%) (RR=2.4; 95% CI, 1.1–3.4).IND vs spontaneous labor 28.1% vs 30.1% (RR=1.0; 95% CI, 0.9–1.2); not statistically significant.NICU admission 4.1% vs 2.8% (RR=1.6; 95% CI, 1.0–2.4).
Dublin, 20003 Population-based cohort study.2886 induced vs 9648 spontaneous labor. 37–41weeks gestation.In nulliparous women 19% of IND group had cesarean delivery vs 10% nulliparous of women in spontaneous labor group (NNH=11). No association was seen in multiparous women.18.6% vs 15.5% (RR=1.2; 95% CI, 1.02–1.32).Shoulder dystocia 3.0% vs 1.7% (RR=1.32; 95% CI, 1.02–1.69); NNH=77.
Nicholson, 20044 Retrospective cohort study.100 women in active management (AM) group, 300 selected subjects in standard management (SM) group. 38 to to 410/7 weeks gestation.AM group vs SM group had higher rates of induction (63% vs 23.7%; risk ratio=2.66 [95% CI, 2.07–3.43]). AM group vs SM group had a lower cesarean delivery rate (4% vs 16.7%; risk ratio=0.24; 95% CI, 0.09–0.65; NNT=7).AM group vs SM group 16% vs 15.3%. Not statically significant.No significant differences.
Nielson, 20055 116 women (45 nulliparous) randomized at ≥39 wks to expectant management or induction with oxytocin and/or amniotomy.6.9% (8/116) IND group. vs 7.3% (8/110) in EM group. Not statistically significant.6.9% (8/116) IND group vs 8.2% (9/116) EM group. Not statistically significant.No mention.
Sanchez-Ramos, 20036Systematic review of 16 randomized controlled trials (6588 women). Included women at 41 weeks gestation.20.1% in IND group vs 22.0% in EM group. NNT=52; odds reduction of 12% (95% CI, 0.78–0.99). Statistically significant.No mention.Perinatal mortality rate: 0.09% IND group vs 0.33% EM group. Not statistically significant.
IND, induction; EM, expectant management; AM, active management; SM, standard management; NICU, neonatal intensive care unit; RR, relative risk; CI, confidence interval; NNT, number needed to treat; NNH, number needed to harm.

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