Clinical Edge

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Bilateral Mastectomy Reduces Second Breast Cancer Risk, but not Death

Key clinical point: Bilateral mastectomy does not decrease risk of breast cancer death, compared with breast-conserving therapy.

Major finding: The hazard ratio for death with bilateral mastectomy versus breast-conserving therapy was 1.03 and was not significant.

Study details: A retrospective study of data on 2435,418 patients diagnosed with breast cancer from 1998 to 2015.

Disclosures: The study was funded by the National Cancer Institute, National Institutes of Health, Department of Health & Human Services, Suzanne Pride Bryan Fund for Breast Cancer Research, Jan Weimer Faculty Chair for Breast Oncology, and the BRCA Foundation. Dr. Kurian disclosed institutional research funding from Myriad Genetics.


Kurian AW et al. Cancer. 2019 Nov 21. doi: 10.1002/cncr.32618.