Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Single-Fraction Radiation Misses Mark for Spinal Compression Relief

Key clinical point: Single-fraction radiation was not noninferior to 5-fraction radiation for treatment of spinal compression at 8 weeks.

Major finding: Among patients in the single-fraction arm, 69.3% had good ambulatory status at 8 weeks, vs. 72.7% of patients in the multi-fraction arm.

Study details: SCORAD trial, a randomized noninferiority trial of 686 patients with spinal compression from metastatic cancers.

Disclosures: Cancer Research UK and Cancer Council Queensland funded the trial. Dr. Hoskin reported being supported by the National Institute for Health Research Manchester Biomedical Research Centre.


Hoskin PJ et al. JAMA 2019 Dec 3. doi: 10.1001/jama.2019.17913.