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Acute Myocardial Infarction During Pregnancy

Mayo Clin Proc; ePub 2018 Jul 18; Smilowitz, et al

Among patients hospitalized during pregnancy and postpartum, acute myocardial infarction (AMI) occurred in 1 of every 12,400 hospitalizations and rates of AMI increased over time, a recent study found. Women aged ≥18 years hospitalized during pregnancy and the puerperium were identified from the National Inpatient Sample database from January 1, 2002, to December 31, 2014. Researchers analyzed trends in the incidence, in-hospital management, and outcomes of AMI complicating pregnancy and the puerperium in the US. They found:

  • Overall, 55,402,290 pregnancy-related hospitalizations were identified.
  • A total of 4,471 cases of AMI (8.1 cases per 100,000 hospitalizations) occurred, with 922 cases (20.6%) identified in the antepartum period, 1,061 (23.7%) during labor and delivery, and 2,390 (53.5%) in the postpartum period.
  • In-hospital maternal mortality was significantly higher in patients with AMI in those without AMI during pregnancy.
  • The rate of AMI during pregnancy and the puerperium increased over time.


Smilowitz NR, Gupta N, Guo Y, et al. Acute myocardial infarction during pregnancy and the puerperium in the United States. [Published online ahead of print July 18, 2018]. Mayo Clin Proc. doi:10.1016/j.mayocp.2018.04.019.