Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Consumption of SSBs & Risk of Mortality

Circulation; ePub 2019 Mar 18; Malik, et al

In 2 large US cohorts, the consumption of sugar-sweetened beverages (SSBs) was positively associated with mortality primarily through cardiovascular disease (CVD) and showed a graded association with dose. Researchers examined associations between consumption of SSBs and artificially sweetened beverages (ASBs) with the risk of total and cause-specific mortality among 37,716 men from the Health Professional’s Follow-up Study and 80,647 women from the Nurses’ Health Study. They found:

  • 36,436 deaths (7,896 CVD and 12,380 cancer deaths) were documented during 3,415,564 person-years of follow-up.
  • Intake of SSBs was positively associated with total mortality showing a graded association with dose, largely caused by CVD mortality. A modest association was observed for cancer mortality.
  • ASB intake was positively associated with total and CVD mortality but not cancer mortality at high intake levels.


Malik VS, Li Y, Pan A, et al. Long-term consumption of sugar-sweetened and artificially sweetened beverages and risk of mortality in US adults. [Published online ahead of print March 18, 2019]. Circulation. doi:10.1161/CIRCULATIONAHA.118.037401.