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Intensive BP Control & Risk of Dementia

JAMA; ePub 2019 Jan 28; SPRINT MIND Investigators

Intensive blood pressure (BP) control did not significantly reduce the risk of probable dementia among adults with hypertension, according to a new study. The randomized clinical trial included 9,361 US adults (mean age 67.9 years; 35.6% women) with hypertension who were randomized to a systolic BP target of <120 mm Hg (intensive treatment group; n=4,678) compared with <140 mm Hg (standard treatment group; n=4,683). The primary cognitive outcome was occurrence of adjudicated probable dementia. Researchers found:

  • During a total median follow-up of 5.11 years, adjudicated probable dementia occurred in 149 participants in the intensive treatment group vs 176 in the standard treatment group (7.2 vs 8.6 cases per 1,000 person-years).
  • Intensive BP control significantly reduced the risk of mild cognitive impairment and the combined rate of mild cognitive impairment or probable dementia.


The SPRINT MIND Investigators for the SPRINT Research Group. Effect of intensive vs standard blood pressure control on probable dementia: A randomized clinical trial. [Published online ahead of print January 28, 2019]. JAMA. doi:10.1001/jama.2018.21442.