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KCCQ Assessments & Death in HFpEF & HFrEF

JAMA Cardiol; ePub 2017 Nov 1; Pokharel, et al

In serial health status evaluations of patients with heart failure (HF), the most recent Kansas City Cardiomyopathy Questionnaire (KCCQ) score was most strongly associated with subsequent death and cardiovascular (CV) hospitalization in heart failure with preserved (HFpEF) and reduced (HFrEF) ejection fractions, according to a recent study. The secondary analysis of 2 randomized controlled clinical trials examined prior, current, and change in KCCQ overall summary scores (KCCQ-os) in 5-point increments, with higher scores indicting better health status. Time to CV death/first HF hospitalization (primary outcome) and all-cause death (secondary outcome) were measured. Researchers found:

  • Of 1,767 total participants, 882 (~50%) were women and mean age (SD) was 71.5 years.
  • Each 5-point difference in prior or current KCCQ-os scores was associated with a 6%-9%% lower risk of subsequent CV death/first HF hospitalization in patients with HFpEF and 6%-8% lower risk for subsequent CV death/first HF hospitalization in patients with HFrEF.
  • In models with the prior and current KCCQ-os, only the current KCCQ-os was significantly associated with 10% and 7% lower risk for subsequent CV death/first HF hospitalization in patients with HFpEF and HFrEF, respectively.

Citation:

Pokharel Y, Khariton Y, Tang Y, et al. Association of serial Kansas City Cardiomyopathy Questionnaire assessments with death and hospitalization in patients with heart failure with preserved and reduced ejection fraction. A secondary analysis of 2 randomized clinical trials. [Published online ahead of print November 1, 2017]. JAMA Cardiol. doi:10.1001/jamacardio.2017.3983.