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Consider This Method to Measure JAK2 Status in MF

Leuk Res; 2017 Dec; Strati, Benton, et al

Saliva testing is an easier and possibly more reliable method than peripheral blood for measuring JAK2 status and assessing V617F allelic burden in transfusion-dependent patients with myelofibrosis (MF), according to a prospective study involving 167 individuals. Investigators used both methods simultaneously on participants who had MF. Among the results:

  • Concordance between the 2 methods was 96%.
  • Sensitivity and specificity were 100% and 90%, respectively.
  • Ongoing transfusion dependency was the only factor linked with false positive results from saliva testing.


Strati P, Benton CB, Manshouri T, et al. JAK2V617F detection and allele burden measurement in saliva vs peripheral blood in patients with myelofibrosis. Leuk Res. 2017;63:53-55. doi:10.1016/j.leukres.2017. 10.016.