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Consider This in Older People Undergoing Allo-SCT

Biol Blood Marrow Transplant; ePub 2017 Jul 19; Jakubowski, et al

T-cell depleted allogeneic hematopoietic stem cell transplantation appears to work just as well in older patients with hematologic malignancies as it does in their younger counterparts, according to a retrospective study involving 214 individuals. Participants were treated at a single center and were aged ≥55 years. 7 in every 10 had myeloid diseases, and most with acute leukemia were in remission. Investigators reviewed the center’s experience with these patients over 11 years. Among the results:

  • With median follow-up of 70 months among survivors, overall survival rate was 44%.
  • Relapse-free survival rate was 41%.
  • Cumulative incidence of non-relapse mortality at day+100 was only 10%.
  • 9% had acute graft versus host disease (GVHD) at day+100.
  • 7% had chronic GVHD at 2 years.
  • Median Karnofsky Performance Scale for patients >2 years posttransplant was 90.

The authors noted that these results are similar to those seen in younger individuals.


Jakubowski A, Petrlik E, Maloy M, et al. T-cell depletion as an alternative approach for patients >55 years undergoing allogeneic stem cell transplantation as curative therapy for hematologic malignancies. [Published online ahead of print July 19, 2017]. Biol Blood Marrow Transplant. doi:10.1016/j.bbmt.2017.06.024.