There are a number of factors that impact the effect of allogeneic stem cell transplantation (HCT) on outcomes in patients with myelofibrosis, according to a recent review. Additionally, new therapeutic areas, such as the use and timing of Janus kinase inhibitors with HCT, are also playing a role.
BCR-ABL1-negative myeloproliferative neoplasm includes primary myelofibrosis, post-essential thrombocythemia myelofibrosis, and post-polycythemia vera myelofibrosis. These diseases present with anemia and splenomegaly, as well as significant constitutional symptoms, such as severe fatigue, symptoms associated with an enlarged spleen and liver, pruritus, fevers, night sweats, and bone pain.
The authors note that while HCT remains the only potentially curative option, there is evidence of the role of JAK inhibitors in providing symptom relief.
Jain T, Mesa, R, Palmer. Allogeneic stem cell transplantation in myelofibrosis. [Published online ahead of print May 9, 2017]. Biol Blood Marrow Transplant. doi:10.1016/j.bbmt.2017.05.007.
This Week's Must Reads
Must Reads in Hematologic Malignancies
Long-term ibrutinib data in older patients, Barr PM et al. Haematologica. 2018;103(9):1502-10
Prognostic Score System for Patients with PMF, J Clin Oncol; ePub 2017 Dec 9; Gugliemelli, et al
These Patients Are More Apt to Be Depressed, Ann Hematol; ePub 2017 Dec 7; Shreders, et al
Survival Length Shortest in These Patients with MF, Eur J Haematol; ePub 2017 Dec 11; Masarova, et al
The Value of Ruxolitinib Before and After AlloSCT, Blood; ePub 2017 Dec 7; Poulose, Malysz, et al