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Predicting Survival in Patients with Post-PV/ET

Leukemia; ePub 2017 Aug 18; Tefferi, Saeed, et al

The 8 risk variables used in 3 scoring systems have predictive value in patients with either post-polycythemia vera (post-PV MF) or post-essential thrombocythemia myelofibrosis (post-ET MF), according to a study involving 125 individuals. Participants had primary MF (PMF), prefibrotic PMF, post-ET MF, or post-PV MF. Investigators looked at whether the 8 variables used in the International Prognostic Scoring System (IPSS), dynamic IPSS (DIPSS), and DIPSS-plus could predict shortened survival in post-PV/ET MF. Among the results:

  • At a median follow-up of 3 years after fibrotic progression began, nearly 70% died.
  • 5 risk variables used in IPSS or DIPSS predicted shortened survival for all but constitutional symptoms.
  • Patients with circulating blasts ≥1%, were more than twice as likely to experience shortened survival.
  • Those with hemoglobin 25 x 109/L were nearly twice as likely to experience such.
  • The 8 risk variables used in DIPSS-plus predicted all except constitutional symptoms and leukocyte count >25 x 109/L with borderline significance.

Citation:

Tefferi A, Saeed L, Hanson CA, Ketterling R, Pardanani A, Gangat N. Application of current prognostic models for primary myelofibrosis in the setting of post polycythemia vera or post-essential thrombocythemia myelofibrosis. [Published online ahead of print August 18, 2017]. Leukemia. doi:10.1038/leu.2017.268.