Symptom burden is greater with people with myelofibrosis (MF) who also have thrombocytopenia than it is in those with MF only, according to a study involving 418 individuals. Participants had MF either with (n=89) or without (n=329) thrombocytopenia. Investigators looked at quality of life and symptom burden. Among the results:
- More patients with thrombocytopenia experienced anemia (76% vs 45%), leukopenia (29% vs 11%), and red blood cell transfusion (35% vs 19%).
- They also had higher levels of fatigue, early satiety, inactivity, dizziness, sad mood, cough, night sweats, itching, fever, and weight loss.
- More patients with severe thrombocytopenia experienced anemia (86% vs 67%), leukopenia (40% vs 20%), and transfusion (51% vs 20%).
- Symptoms in patients with severe vs moderate thrombocytopenia were similar.
Scotch AH, Kosiorek H, Scherber R, et al. Symptom burden profile in myelofibrosis patients with thrombocytopenia: Lessons and unmet needs. Leuk Res. 2017;63:34-40. doi:10.1016/j.leukres.2017.10.002.
This Week's Must Reads
Must Reads in Hematologic Malignancies
Long-term ibrutinib data in older patients, Barr PM et al. Haematologica. 2018;103(9):1502-10
Prognostic Score System for Patients with PMF, J Clin Oncol; ePub 2017 Dec 9; Gugliemelli, et al
These Patients Are More Apt to Be Depressed, Ann Hematol; ePub 2017 Dec 7; Shreders, et al
Survival Length Shortest in These Patients with MF, Eur J Haematol; ePub 2017 Dec 11; Masarova, et al
The Value of Ruxolitinib Before and After AlloSCT, Blood; ePub 2017 Dec 7; Poulose, Malysz, et al