Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Ultrasonography Screening in Breast Cancer

JAMA Intern Med; ePub 2019 Mar 18; Lee, et al

The benefits of supplemental ultrasonography screening may not outweigh associated harms, a new study found. Researchers sought to determine the performance of screening mammography plus screening ultrasonography compared with screening mammography alone in community practice. They found:

  • Screening mammography with vs without ultrasonography examinations was performed more often in women with dense breasts, in women aged <50 years, and in women with a family history of breast cancer.
  • For women with breast cancer risk ranging from low to very high, there were significantly higher short-interval follow-up and therapy recommendation rates with screening mammography plus same-day ultrasonography vs mammography alone.
  • However, no significant increase in cancer detection or decrease in interval cancers rates were observed.


Lee JM, Arao RF, Sprague BL, et al. Performance of screening ultrasonography as an adjunct to screening mammography in women across the spectrum of breast cancer risk. [Published online ahead of print March 18, 2019]. JAMA Intern Med. doi:10.1001/jamainternmed.2018.8372.