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Alcohol and genes connect to promote aggressive prostate cancer

Key clinical point: The impact of excessive alcohol intake contributes variously to the development of aggressive prostate cancer according to genetic profiles.

Major finding: The interaction of excessive alcohol intake and three SNPs (rs13107662, rs9907521, and rs11925452) were significantly associated with increased risk of more aggressive disease in prostate cancer patients.

Study details: The data come from a review of 3,306 prostate cancer patients with three excessive alcohol intake behaviors.

Disclosures: The study was supported by the National Cancer Institute. The researchers had no financial conflicts to disclose.

Commentary

An accurate understanding of the risk factors for the incidence and aggressiveness of prostate cancer is critical to developing strategies to address the factors that are modifiable. Previous studies have suggested a potential association between alcohol consumption and prostate cancer aggressiveness, but the nature and degree of the association remains unclear. Lin et al. evaluated whether single nucleotide polymorphisms (SNPs) modify the effects of alcohol on the aggressiveness of prostate cancer. They did not identify an association between excessive alcohol intact and the aggressiveness of prostate cancer in the overall cohort; however, they did identify such an association for 3 SNPs (to CAMK2D, PRKCA, and ROBO1). The results suggest that further extensive genetic studies are needed better understand the likely complex interaction between alcohol intake and prostate cancer aggressiveness.”

Mark Klein, MD

Citation:

Lin H-Y et al. J Clin Med. 2021 Feb 2. doi: 10.3390/jcm1003055.