DDSEP® 8 Quick Quiz

Question 1

Q1. A 25-year-old woman with colonic Crohn's disease presents for routine follow-up. She is in remission on her regimen of vedolizumab. When discussing her medication regimen, she asks about the long-term risks associated with her Crohn's disease and treatment.

Which of the following is she at increased risk for because of her diagnosis?

Breast adenomas


Vaginal atrophy

Ovarian cysts

Cervical dysplasia

Correct answer : E. Cervical dysplasia.

In a nationwide cohort study, women with Crohn's disease and ulcerative colitis were found to have an increased risk of cervical dysplasia. Patients with ulcerative colitis had increased risks of low- and high-grade squamous intraepithelial lesions, whereas patients with Crohn's disease also had increased risks of cervical cancer. Age-appropriate screening with pap smears is important for women diagnosed with inflammatory bowel disease regardless of treatment type.

Rungoe et al. Clin Gastroenterol Hepatol. 2015 Apr;13(4):693-700.e1.

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