DDSEP® 8 Quick Quiz

Question 2


Which of the following is not a known risk factor for gastric cancer?

Lynch syndrome

Selenium exposure

Menetrier's disease

Germline mutation in E-cadherin gene

Peutz-Jeghers syndrome

Correct answer: B. Selenium exposure.

Helicobacter pylori infection is by far the most important risk factor for gastric cancer worldwide. Less common risk factors for gastric cancer include Lynch syndrome, Peutz-Jeghers syndrome, Menetrier's disease, and germline mutations in the CDH gene (encoding E-cadherin). However, there is some evidence that selenium, as well as high consumption of fruits and vegetables, may have protective effects against gastric cancer.

de Martel C et al. Gastroenterol Clin North Am. 2013 Jun;42(2):219-40.
Giardiello FM et al. N Engl J Med. 1987 Jun 11;316(24):1511-4.
Qiao YL et al. J Natl Cancer Inst. 2009 Apr 1;101(7):507-18.

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