From the Journals

Newborn oral rotavirus vaccine held effective



A new oral rotavirus vaccine administered within the first few days of life appears effective against severe rotavirus gastroenteritis in newborns, a study has found.

A transmission electron micrograph shows intact rotavirus double-shelled particles. CDC/Dr. Erskine Palmer
When all three doses were administered, vaccine efficacy with the neonatal schedule was 75% by 18 months of age (P less than .001), while the efficacy of the infant schedule at 18 months was 51% (P = .03), and in the two groups combined, the efficacy was 63% (P less than .001) in the per-protocol analysis, the researchers reported in the New England Journal of Medicine. The results were similar in the intention-to-treat analysis.

At 12 months of age, the rotavirus vaccine showed an efficacy of 94% in participants who received all three doses of the neonatal schedule. That efficacy was 77% in those who received the doses on the infant schedule.


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