Conference Coverage

Prehospital antibiotics improved some aspects of sepsis care



The primary end point of the study was all-cause mortality at 28 days.

The negative mortality results of this trial are “not surprising,” given that the trial’s inclusion criteria allowed individuals with suspected infection but without organ dysfunction, said Jean-Louis Vincent, MD, PhD, of Erasmus Hospital, Brussels, in a related editorial appearing in the Lancet Respiratory Medicine (2018 Jan. doi: 10.1016/S2213-2600[17]30446-0).

Recent consensus definitions of sepsis recognize that sepsis is the association of an infection with some degree of organ dysfunction, according to Dr. Vincent.

“After this initial experience, I believe that a randomized, controlled trial could be done to assess the potential benefit of early antibiotic administration in the ambulance for patients with organ dysfunction associated with infection,” Dr. Vincent wrote in his editorial.

Dr. Nanayakkara and his coauthors declared no competing interests related to their study.

SOURCE: Alam N et al. Lancet Respir Med. 2018 Jan;6(1):40-50.


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