Clinical Edge Journal Scan

Serious infections arise in pediatric transplant patients


Key clinical point: Fungal or bacterial bloodstream infections were common in children within 5 years of liver or kidney transplants; the overall incidence in the first year post-transplant was 1.91 per 100 recipients per month.

Major finding: A total of 29 of 85 children who underwent liver or kidney transplants developed bacterial or fungal bloodstream infections within 5 years of their transplants with 16 different pathogens; the most common were Enterococcus faecium, Candida albicans , Escherichia coli , and Klebsiella pneumoniae .

Study details: The data come from a prospective study of 85 pediatric patients who underwent liver and kidney transplants between 2010 and 2017; the total follow-up was 390 person-years.

Disclosures: The study was supported by the Novo Nordic Foundation, the Independent Research Fund (FSS), the Danish National Research Foundation (DNRF), and the Research Foundation of Rigshospitalet; several coauthors also disclosed support from these organizations, as well as from Gilead and Merck.

Source: Møller DL et al. BMC Infect Dis. 2021 Jun 8. doi: 10.1186/s12879-021-06224-2.

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