CME Supplements

Diagnosing and Managing Depressive Episodes in the DSM-5 Era

This activity is jointly provided by RMEI, LLC and Postgraduate Institute for Medicine. This activity is supported by an independent educational grant from Sunovion.


The premise of the newly introduced mixed features specifier in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) is similar to what was proposed approximately a century ago as part of the “manic depression” unification hypothesis. German psychiatrist Emil Kraepelin (1856–1926) originally conceptualized affective states as a continuum, wherein an individual’s diagnosis was arrived at via a confluence of contemporaneous disturbances in mood, thought processes, and volition (behavior). His original description was agnostic insofar as it lacked the 2 categorical constructs, bipolar disorder and major depressive disorder—terms that eventually appeared in the DSM.

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