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Frontal White Matter Predicts Efficacy of DBS in Major Depression

In 2 trials of deep brain stimulation (DBS) to the superolateral medial forebrain bundle, biomarkers that may allow identification of future responders to DBS therapy in major depression (MD) showed potential as a step toward personalized treatments for psychiatric disorders. Data from 24 patients were analyzed. The goal was to identify informed features that allow to predict treatment response. Researchers found:

  • A left fronto-polar and party orbitofrontal region was identified that showed increased volume in preoperative anatomical scans.
  • Statistical analysis showed that the volume of this “HUB-region” is predictive for later MADRS response from DBS.
  • The HUB region connects to typical fiber pathways that have been addressed before in therapeutic DBS in MD.
  • Left frontal volume growth may indicate intrinsic activity upon disconnection from the main emotional network.

Citation:

Coenen VA, et al. Frontal white matter architecture predicts efficacy of deep brain stimulation in major depression. [Published online ahead of print August 21, 2019]. Transl Psychiatry. doi: 10.1038/s41398-019-0540-4.