Clinical Edge

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Weight loss may be paramount lifestyle change in preventing gout

Key clinical point: Addressing four lifestyle factors has the potential to reduce the incidence of new gout cases by 77%.

Major finding: Without modifying obesity, none of the other preventive lifestyle risk factors alone reached significance.

Data source: A prospective cohort study of 44,654 men who were enrolled in the Health Professionals Follow-up Study and followed during 1986-2012.

Disclosures: This research was supported by grants from the National Institutes of Health. Dr. Choi reported receiving research support from Ironwood and Horizon and consulting fees from Ironwood, Selecta, Horizon, Takeda, Kowa, and Vaxart. No other relevant financial disclosures were reported.


McCormick N et al. JAMA Netw Open. 2020;3(11):e2027421. doi: 10.1001/jamanetworkopen.2020.27421.