Diagnostic value of the physical examination in patients with dyspnea

Laennec’s stethoscope has survived more than 200 years, much longer than some of his contemporaries predicted. But will it survive the challenge of bedside ultrasonography and other technologic advances?

The physical examination, with its roots extending at least as far back as Hippocrates, may be at a crossroads as the mainstay of diagnosis. Physical signs can be subjective and lack sensitivity and specificity. Modern imaging and laboratory studies may already be more trusted.

If the physical examination is to survive, it must be accurate, reproducible, and efficient. Needed is a simple, evidence-based approach to the physical examination that enhances its diagnostic accuracy while maintaining bedside efficiency.

Here, we analyze the accuracy of the physical signs that are most effective in the clinical diagnosis of 4 common cardiopulmonary conditions that often present with dyspnea: pneumonia, pleural effusion, chronic obstructive pulmonary disease (COPD), and congestive heart failure.

LIKELIHOOD RATIOS

To grasp the significance of physical findings, it is necessary to understand the concept of likelihood ratios, which are widely accepted measures of the accuracy of a test or clinical finding.^1,2 The positive likelihood ratio is the probability of a disease being present when the test is positive or the clinical finding is present, while the negative likelihood ratio is the probability that the disease is present when the test is negative or the clinical finding is absent. They are calculated as follows¹:

Positive likelihood ratio = sensitivity / (1 – specificity)

Negative likelihood ratio = (1 – sensitivity) / specificity

Or more simply, they are calculated as the probability of the finding in patients with the disease, divided by the probability of the same finding in patients without the disease.² Thus, the higher the positive likelihood ratio, the greater the probability that a patient who has a positive finding actually has the disease. Conversely, the lower the negative likelihood ratio, the lower the probability that a person without the finding actually has the disease. A likelihood ratio of 1 means the test or finding is no better than chance.

Table 1 shows how the likelihood ratio of a test changes the posttest probability that a condition is present or absent, according to an analysis by McGee.²

STANDARDIZED TERMINOLOGY

The International Lung Sounds Association³ has proposed standard terminology for describing findings on chest auscultation, as the terminology used until now was considered imprecise. For simplicity, respiratory sounds can be described as either normal or abnormal (adventitious) (Table 2).⁴

PNEUMONIA

Pneumonia is a common disease, with more than 2 million cases annually in the United States. It is most often diagnosed by standard chest radiography, although computed tomography can identify it earlier and with higher sensitivity and specificity.⁵ The amount of published data on physical examination findings in pneumonia is surprisingly small.

Asymmetry in chest expansion: Specific, reproducible, but not sensitive

The physical finding with the highest positive likelihood ratio for diagnosing pneumonia is asymmetry in chest expansion.^6,7

From Diaz-Guzman E, Budev MM. Accuracy of the physical examination in evaluating pleural effusion. Cleve Clin J Med 2008; 75:297–303.

Chest expansion is typically examined posteriorly, with the thumbs placed together along the midline of the spine and the 4 fingers held together with the index finger below the 10th rib (Figure 1). As the patient takes a deep breath, the physician feels for asymmetric movement of his or her thumbs.

In a 1984 study of 1,819 patients presenting to an emergency department with acute cough, Diehr et al⁶ evaluated several physical signs of pneumonia. Asymmetric chest expansion had a specificity and positive predictive value of 100%, but its sensitivity was only 4.3%. Thus, it is not a good screening test, but it is a good diagnostic or confirmatory test. From these numbers, Metlay et al⁸ calculated that the positive likelihood ratio was infinity and the negative likelihood ratio was 0.96.

McGee,⁷ on the other hand, calculated the positive likelihood ratio of asymmetric chest expansion at 44.1. McGee also found chest expansion to be a highly reproducible finding, with an interobserver agreement kappa score of 0.85.⁷ (A kappa score of 1.0 would indicate perfect interobserver agreement.) Interestingly, chest radiographs interpreted for pulmonary infiltrates have an interobserver kappa score of only 0.38.⁷ Further studies of this physical sign could shed more light upon this area of uncertainty.

Other signs of pneumonia

None of the other physical signs studied for the diagnosis of pneumonia has as high a positive likelihood ratio as asymmetric chest expansion.^6–12

Egophony is a high-pitched or nasal quality of the patient’s voice heard on auscultation over lung tissue that is consolidated or fibrosed, due to enhanced transmission of high-frequency sound across fluid. It is often described as the “E-to-A change.” Although listening for egophony is widely done and easy to do, we calculate that this sign has a positive likelihood ratio of only 6.8 based on pooled data from 3 trials with a total of 3,245 patients.^6,10,11

Faring less favorably, in descending order of diagnostic accuracy, are:

Percussion dullness (positive likelihood ratio 5.7 based on 4 studies with 3,653 patients)^6,10–12

Bronchophony or bronchial breath sounds (positive likelihood ratio 3.3 based on 1,118 patients)¹⁰

Crackles have long been taught as a common physical finding in pneumonia. Bohadana et al pointed out that “crackle” can be defined acoustically but does not suggest any means or site of generation.⁴ Pooled data from 4 studies in 3,647 patients^6,10–12 result in a positive likelihood ratio for crackles in the diagnosis of pneumonia of only 3.2.

Diminished breath sounds (positive likelihood ratio 2.5 based on 3 studies with 1,828 patients).^10–12

 

 

Consider pneumonia signs in combination

These physical examination maneuvers are time-honored and part of the rite of training for medical students and residents. As we have shown, they are not extremely helpful as individual tests in diagnosing pneumonia; however, they may be useful when used in combination as a clinical prediction rule or diagnostic algorithm. These rules often have higher diagnostic accuracy but drawbacks of taking more time and not being easily reproducible.

None of these physical findings has a very low (clinically significant) negative likelihood ratio; therefore, their absence is not useful in ruling out pneumonia. The positive and negative likelihood ratios for these physical signs are summarized in Table 3.^6,9–14

PLEURAL EFFUSION

Pleural effusion commonly occurs in patients with congestive heart failure, pneumonia, and malignancies. The following are signs of effusion.

Dullness to percussion had a positive likelihood ratio of 5.7 from pooled data from 3 studies analyzed by Wong et al.¹³

Asymmetric chest expansion, in a study by Kalantri et al,¹⁴ had a positive likelihood ratio of 8.1 and a negative likelihood ratio of 0.29, the latter making it a reasonably good test to help rule out a pleural effusion.

Negative signs. Since a pleural effusion is an abnormal fluid collection in the pleural space and not the lung parenchyma, one would not expect it to cause loud breath sounds, adventitious sounds, or vocal resonance. Since these 3 findings emanate from the lung, their absence would be expected to support the presence of a pleural effusion.

Tactile fremitus, also known as vocal fremitus, is the vibration felt on the chest wall while the patient is speaking. Traditionally, the patient says “ninety-nine” as the examiner feels for asymmetry in vibration. A consolidation such as pneumonia increases the vibration, while fluid in a pleural effusion diminishes it.

To summarize, diminished breath sounds, diminished tactile fremitus, and diminished vocal resonance (either egophony or bronchophony) should support a diagnosis of a pleural effusion. As expected, the evidence supports these tests, which have very good negative likelihood ratios (Table 4).¹⁴ Tactile fremitus, loud breath sounds, or vocal resonance, if present, make pleural effusion very unlikely.

DIAGNOSTIC ALGORITHM FOR PNEUMONIA OR PLEURAL EFFUSION

Patients presenting with cough or dyspnea will most likely be evaluated for pneumonia and pleural effusion, among other diagnoses. We propose the following physical examination strategy in this setting.

First, evaluate the patient for asymmetric chest expansion. The positive likelihood ratio for this sign is excellent for pneumonia (44.1) and moderate for pleural effusion (8.1); therefore, both conditions are possible with a positive test.

Second, percuss the chest. Dullness to percussion has a low positive likelihood ratio for pneumonia but a moderate one for pleural effusion.¹³ The absence of this sign is only modest in excluding a pleural effusion (negative likelihood ratio 0.31 in pooled data analyzed by Wong et al).¹³

Third, auscultate the chest to elicit normal, diminished, or adventitious breath sounds. Diminished breath sounds may be noted in both conditions, but vocal resonance (egophony or bronchophony) and tactile fremitus should not be present directly over a pleural effusion. Either vocal resonance or tactile fremitus in a patient with asymmetric chest expansion would strongly support the diagnosis of pneumonia.

In a parapneumonic effusion or pneumonia with a concomitant empyema, a combination of findings may be present. In this case the pneumonia will be superior to the effusion and the characteristic findings for each should be present over the areas of disease in the lung.

Figure 2 summarizes our proposed diagnostic algorithm for pneumonia and pleural effusion.

CHRONIC OBSTRUCTIVE PULMONARY DISEASE

COPD imposes a heavy burden on public health worldwide in terms of cost and mortality. It is the third leading cause of death in the United States, after heart disease and cancer.¹⁵

Spirometry remains the gold standard for diagnosis. The Global Initiative for Chronic Obstructive Lung Disease standard for diagnosing COPD was the better of 2 spirometry test results, showing a forced expiratory volume in 1 second (FEV₁) and FEV₁/forced vital capacity ratio less than 70%.¹⁶

Unfortunately, there is little evidence that physical signs aid in the early diagnosis of COPD, as physical signs of airflow limitation may not manifest until lung function is substantially impaired.^17,18

Early inspiratory crackles had a positive likelihood ratio of 14.6 based on 2 small studies.^19,20

Percussion dullness over the left sternal border in the fifth intercostal space should be present in the normal situation and is known as cardiac dullness. Absent cardiac dullness had a positive likelihood ratio of 16 and a negative likelihood ratio of 0.8 for diagnosing COPD in a study in 92 patients with a history of smoking or self-reported COPD.²¹ The kappa score was 0.49, signifying moderate interobserver  agreement.

A combined strategy using the history and physical examination may have the highest diagnostic accuracy. Many of these combinations are too cumbersome for practical clinical use. However, 1 of them is based on only 3 questions²¹:

• Has the patient smoked for more than 70-pack years?
• Has the patient been previously diagnosed with chronic bronchitis or emphysema?
• Are breath sounds diminished in intensity?

Answering yes to 2 of these questions gives a positive likelihood ratio of a diagnosis of COPD of 33.5.

Early detection of COPD may improve outcomes and lower healthcare costs and thus would be clinically useful. Unfortunately, a diagnostic approach using the history and physical in the early diagnosis of COPD remains uncertain at this time.

 

 

CONGESTIVE HEART FAILURE

The clinical presentation of acute congestive heart failure has much in common with pneumonia, pleural effusion, and COPD.

Echocardiography, the gold standard for diagnosis, is costly and may not be immediately available for most patients evaluated for cardiorespiratory complaints. The American College of Cardiology reports the cost of standard echocardiography to be between $1,000 and $2,000.²² A physical examination approach in the assessment of dyspnea can be very useful.

Height of jugular venous distention approximates central venous pressure

Assessing the central venous pressure by estimating the vertical height of distention of the right internal or external jugular vein is validated and easily reproducible.^23,24 The use of the external jugular vein is supported by correlation with catheter-measured central venous pressure in critically ill patients.^25,26 The central venous pressure reflects the right atrial pressure, and in the absence of tricuspid stenosis, the right ventricular end-diastolic pressure. An elevation in central venous pressure can be seen in patients with congestive heart failure, pulmonary hypertension, and pulmonary valve stenosis.

The right side is preferred due to its anatomically direct route to the heart. In contrast, the left internal jugular vein crosses the mediastinum and can be compressed by the aorta, causing a false elevation.

Examination of the jugular venous pressure has good accuracy in the evaluation of elevated central venous pressure. Examination of the neck veins can detect a central venous pressure elevation of 8 cm with a positive likelihood ratio of 9.7 and a corresponding negative likelihood ratio of 0.3.^23–26 Detecting a jugular venous pressure elevation of 12 cm results in a positive likelihood ratio of 10.4 and a negative likelihood ratio of 0.1 (Table 5).^23,24

In summary, an elevated jugular venous pressure on examination is a good test to rule in an elevated central venous pressure, and its absence is a good sign in ruling out an elevated central venous pressure. When using jugular venous pressure specifically for the diagnosis of congestive heart failure with reduced ejection fraction (ie, ejection fraction < 50%), the positive likelihood ratio is 6.3 based on 3 studies.^25–27

Heart failure with preserved ejection fraction has not been well studied for physical examination. The Irbesartan in Heart Failure with Preserved Ejection Fraction Trial (I-Preserve)²⁸ looked only at the sensitivity of elevated jugular venous pressure in 4,128 patients, which was 8%. Specificity was not reported.

The abdominojugular reflux

Another way to gauge the jugular venous pressure is to examine the neck veins while firmly pressing on the mid-abdomen for 10 to 15 seconds to look for the abdominojugular reflux, also known as the hepatojugular reflux. An increase in the jugular venous pressure of 3 cm from baseline constitutes a positive abdominojugular reflux. It has a positive likelihood ratio of 8.0 and a negative likelihood ratio of 0.3 for the diagnosis of congestive heart failure by the assessment of end-diastolic pressure of the left ventricle (Table 5).^29–31

The abdominojugular reflux is a much more reliable test than examination of neck veins for jugular venous pressure. The interobserver agreement for examining neck veins has a wide range of kappa scores (0.08–0.81), whereas the abdominojugular reflux has a very high kappa score of 0.92.⁷ Interestingly, chest radiography showing interstitial edema has a kappa of 0.83.⁷

Displaced apical impulse

An evaluation of the apical impulse of the heart is also a very good and quick test in the examination of patients suspected of having congestive heart failure. An abnormal finding is defined by an apical impulse displaced laterally (to the left of the midclavicular line).

Using data from several studies,^32–35 a displaced apical impulse has a positive likelihood ratio of 10.3. The absence of this finding, however, is not very good for ruling out congestive heart failure, with a negative likelihood ratio of 0.7. Interobserver agreement is moderate to excellent (kappa score 0.43–0.86).⁷

A third heart sound

Auscultation to assess the third heart sound is much more difficult. A systematic review found that likelihood ratios vary widely and confidence intervals are wide.³⁶ Interobserver agreement also varies widely (kappa scores –0.17 to 0.84).⁷ In a primary care study,³⁷ a third heart sound had a very low sensitivity (4.3%) but a specificity of 99.8%.

Therefore, we are uncertain about a conclusion for this physical finding based on the concern for wide ranges in likelihood ratio and poor interobserver reliability.

PHYSICAL EXAMINATION STILL HAS A FUTURE

The physical examination has a long and distinguished place in the history of medicine. Technologic advances have changed the manner in which clinicians practice the art of healing. Modern technology in US healthcare has become a double-edged sword, with many benefits as well as detriments.³ Reproducibility and accuracy are paramount for the physical examination to remain a core component of medical diagnosis. Advances in the diagnostic accuracy of laboratory and imaging studies challenge the importance of the physical examination. However, we firmly believe that the traditional techniques have stood the test of time and have a future in the clinical practice of medicine.

Acknowledgments: The authors thank Ruby Marr, MD, Mohammed Nabhan, MD, Rajiv Doddamani, MD, and Sohaib Galani, MD, for their important contributions to this article, which included research assistance and editorial advice.

Laennec’s stethoscope has survived more than 200 years, much longer than some of his contemporaries predicted. But will it survive the challenge of bedside ultrasonography and other technologic advances?

The physical examination, with its roots extending at least as far back as Hippocrates, may be at a crossroads as the mainstay of diagnosis. Physical signs can be subjective and lack sensitivity and specificity. Modern imaging and laboratory studies may already be more trusted.

If the physical examination is to survive, it must be accurate, reproducible, and efficient. Needed is a simple, evidence-based approach to the physical examination that enhances its diagnostic accuracy while maintaining bedside efficiency.

Here, we analyze the accuracy of the physical signs that are most effective in the clinical diagnosis of 4 common cardiopulmonary conditions that often present with dyspnea: pneumonia, pleural effusion, chronic obstructive pulmonary disease (COPD), and congestive heart failure.

LIKELIHOOD RATIOS

To grasp the significance of physical findings, it is necessary to understand the concept of likelihood ratios, which are widely accepted measures of the accuracy of a test or clinical finding.^1,2 The positive likelihood ratio is the probability of a disease being present when the test is positive or the clinical finding is present, while the negative likelihood ratio is the probability that the disease is present when the test is negative or the clinical finding is absent. They are calculated as follows¹:

Positive likelihood ratio = sensitivity / (1 – specificity)

Negative likelihood ratio = (1 – sensitivity) / specificity

Or more simply, they are calculated as the probability of the finding in patients with the disease, divided by the probability of the same finding in patients without the disease.² Thus, the higher the positive likelihood ratio, the greater the probability that a patient who has a positive finding actually has the disease. Conversely, the lower the negative likelihood ratio, the lower the probability that a person without the finding actually has the disease. A likelihood ratio of 1 means the test or finding is no better than chance.

Table 1 shows how the likelihood ratio of a test changes the posttest probability that a condition is present or absent, according to an analysis by McGee.²

STANDARDIZED TERMINOLOGY

The International Lung Sounds Association³ has proposed standard terminology for describing findings on chest auscultation, as the terminology used until now was considered imprecise. For simplicity, respiratory sounds can be described as either normal or abnormal (adventitious) (Table 2).⁴

PNEUMONIA

Pneumonia is a common disease, with more than 2 million cases annually in the United States. It is most often diagnosed by standard chest radiography, although computed tomography can identify it earlier and with higher sensitivity and specificity.⁵ The amount of published data on physical examination findings in pneumonia is surprisingly small.

Asymmetry in chest expansion: Specific, reproducible, but not sensitive

The physical finding with the highest positive likelihood ratio for diagnosing pneumonia is asymmetry in chest expansion.^6,7

From Diaz-Guzman E, Budev MM. Accuracy of the physical examination in evaluating pleural effusion. Cleve Clin J Med 2008; 75:297–303.

Chest expansion is typically examined posteriorly, with the thumbs placed together along the midline of the spine and the 4 fingers held together with the index finger below the 10th rib (Figure 1). As the patient takes a deep breath, the physician feels for asymmetric movement of his or her thumbs.

In a 1984 study of 1,819 patients presenting to an emergency department with acute cough, Diehr et al⁶ evaluated several physical signs of pneumonia. Asymmetric chest expansion had a specificity and positive predictive value of 100%, but its sensitivity was only 4.3%. Thus, it is not a good screening test, but it is a good diagnostic or confirmatory test. From these numbers, Metlay et al⁸ calculated that the positive likelihood ratio was infinity and the negative likelihood ratio was 0.96.

McGee,⁷ on the other hand, calculated the positive likelihood ratio of asymmetric chest expansion at 44.1. McGee also found chest expansion to be a highly reproducible finding, with an interobserver agreement kappa score of 0.85.⁷ (A kappa score of 1.0 would indicate perfect interobserver agreement.) Interestingly, chest radiographs interpreted for pulmonary infiltrates have an interobserver kappa score of only 0.38.⁷ Further studies of this physical sign could shed more light upon this area of uncertainty.

Other signs of pneumonia

None of the other physical signs studied for the diagnosis of pneumonia has as high a positive likelihood ratio as asymmetric chest expansion.^6–12

Egophony is a high-pitched or nasal quality of the patient’s voice heard on auscultation over lung tissue that is consolidated or fibrosed, due to enhanced transmission of high-frequency sound across fluid. It is often described as the “E-to-A change.” Although listening for egophony is widely done and easy to do, we calculate that this sign has a positive likelihood ratio of only 6.8 based on pooled data from 3 trials with a total of 3,245 patients.^6,10,11

Faring less favorably, in descending order of diagnostic accuracy, are:

Percussion dullness (positive likelihood ratio 5.7 based on 4 studies with 3,653 patients)^6,10–12

Bronchophony or bronchial breath sounds (positive likelihood ratio 3.3 based on 1,118 patients)¹⁰

Crackles have long been taught as a common physical finding in pneumonia. Bohadana et al pointed out that “crackle” can be defined acoustically but does not suggest any means or site of generation.⁴ Pooled data from 4 studies in 3,647 patients^6,10–12 result in a positive likelihood ratio for crackles in the diagnosis of pneumonia of only 3.2.

Diminished breath sounds (positive likelihood ratio 2.5 based on 3 studies with 1,828 patients).^10–12

 

 

Consider pneumonia signs in combination

These physical examination maneuvers are time-honored and part of the rite of training for medical students and residents. As we have shown, they are not extremely helpful as individual tests in diagnosing pneumonia; however, they may be useful when used in combination as a clinical prediction rule or diagnostic algorithm. These rules often have higher diagnostic accuracy but drawbacks of taking more time and not being easily reproducible.

None of these physical findings has a very low (clinically significant) negative likelihood ratio; therefore, their absence is not useful in ruling out pneumonia. The positive and negative likelihood ratios for these physical signs are summarized in Table 3.^6,9–14

PLEURAL EFFUSION

Pleural effusion commonly occurs in patients with congestive heart failure, pneumonia, and malignancies. The following are signs of effusion.

Dullness to percussion had a positive likelihood ratio of 5.7 from pooled data from 3 studies analyzed by Wong et al.¹³

Asymmetric chest expansion, in a study by Kalantri et al,¹⁴ had a positive likelihood ratio of 8.1 and a negative likelihood ratio of 0.29, the latter making it a reasonably good test to help rule out a pleural effusion.

Negative signs. Since a pleural effusion is an abnormal fluid collection in the pleural space and not the lung parenchyma, one would not expect it to cause loud breath sounds, adventitious sounds, or vocal resonance. Since these 3 findings emanate from the lung, their absence would be expected to support the presence of a pleural effusion.

Tactile fremitus, also known as vocal fremitus, is the vibration felt on the chest wall while the patient is speaking. Traditionally, the patient says “ninety-nine” as the examiner feels for asymmetry in vibration. A consolidation such as pneumonia increases the vibration, while fluid in a pleural effusion diminishes it.

To summarize, diminished breath sounds, diminished tactile fremitus, and diminished vocal resonance (either egophony or bronchophony) should support a diagnosis of a pleural effusion. As expected, the evidence supports these tests, which have very good negative likelihood ratios (Table 4).¹⁴ Tactile fremitus, loud breath sounds, or vocal resonance, if present, make pleural effusion very unlikely.

DIAGNOSTIC ALGORITHM FOR PNEUMONIA OR PLEURAL EFFUSION

Patients presenting with cough or dyspnea will most likely be evaluated for pneumonia and pleural effusion, among other diagnoses. We propose the following physical examination strategy in this setting.

First, evaluate the patient for asymmetric chest expansion. The positive likelihood ratio for this sign is excellent for pneumonia (44.1) and moderate for pleural effusion (8.1); therefore, both conditions are possible with a positive test.

Second, percuss the chest. Dullness to percussion has a low positive likelihood ratio for pneumonia but a moderate one for pleural effusion.¹³ The absence of this sign is only modest in excluding a pleural effusion (negative likelihood ratio 0.31 in pooled data analyzed by Wong et al).¹³

Third, auscultate the chest to elicit normal, diminished, or adventitious breath sounds. Diminished breath sounds may be noted in both conditions, but vocal resonance (egophony or bronchophony) and tactile fremitus should not be present directly over a pleural effusion. Either vocal resonance or tactile fremitus in a patient with asymmetric chest expansion would strongly support the diagnosis of pneumonia.

In a parapneumonic effusion or pneumonia with a concomitant empyema, a combination of findings may be present. In this case the pneumonia will be superior to the effusion and the characteristic findings for each should be present over the areas of disease in the lung.

Figure 2 summarizes our proposed diagnostic algorithm for pneumonia and pleural effusion.

CHRONIC OBSTRUCTIVE PULMONARY DISEASE

COPD imposes a heavy burden on public health worldwide in terms of cost and mortality. It is the third leading cause of death in the United States, after heart disease and cancer.¹⁵

Spirometry remains the gold standard for diagnosis. The Global Initiative for Chronic Obstructive Lung Disease standard for diagnosing COPD was the better of 2 spirometry test results, showing a forced expiratory volume in 1 second (FEV₁) and FEV₁/forced vital capacity ratio less than 70%.¹⁶

Unfortunately, there is little evidence that physical signs aid in the early diagnosis of COPD, as physical signs of airflow limitation may not manifest until lung function is substantially impaired.^17,18

Early inspiratory crackles had a positive likelihood ratio of 14.6 based on 2 small studies.^19,20

Percussion dullness over the left sternal border in the fifth intercostal space should be present in the normal situation and is known as cardiac dullness. Absent cardiac dullness had a positive likelihood ratio of 16 and a negative likelihood ratio of 0.8 for diagnosing COPD in a study in 92 patients with a history of smoking or self-reported COPD.²¹ The kappa score was 0.49, signifying moderate interobserver  agreement.

A combined strategy using the history and physical examination may have the highest diagnostic accuracy. Many of these combinations are too cumbersome for practical clinical use. However, 1 of them is based on only 3 questions²¹:

• Has the patient smoked for more than 70-pack years?
• Has the patient been previously diagnosed with chronic bronchitis or emphysema?
• Are breath sounds diminished in intensity?

Answering yes to 2 of these questions gives a positive likelihood ratio of a diagnosis of COPD of 33.5.

Early detection of COPD may improve outcomes and lower healthcare costs and thus would be clinically useful. Unfortunately, a diagnostic approach using the history and physical in the early diagnosis of COPD remains uncertain at this time.

 

 

CONGESTIVE HEART FAILURE

The clinical presentation of acute congestive heart failure has much in common with pneumonia, pleural effusion, and COPD.

Echocardiography, the gold standard for diagnosis, is costly and may not be immediately available for most patients evaluated for cardiorespiratory complaints. The American College of Cardiology reports the cost of standard echocardiography to be between $1,000 and $2,000.²² A physical examination approach in the assessment of dyspnea can be very useful.

Height of jugular venous distention approximates central venous pressure

Assessing the central venous pressure by estimating the vertical height of distention of the right internal or external jugular vein is validated and easily reproducible.^23,24 The use of the external jugular vein is supported by correlation with catheter-measured central venous pressure in critically ill patients.^25,26 The central venous pressure reflects the right atrial pressure, and in the absence of tricuspid stenosis, the right ventricular end-diastolic pressure. An elevation in central venous pressure can be seen in patients with congestive heart failure, pulmonary hypertension, and pulmonary valve stenosis.

The right side is preferred due to its anatomically direct route to the heart. In contrast, the left internal jugular vein crosses the mediastinum and can be compressed by the aorta, causing a false elevation.

Examination of the jugular venous pressure has good accuracy in the evaluation of elevated central venous pressure. Examination of the neck veins can detect a central venous pressure elevation of 8 cm with a positive likelihood ratio of 9.7 and a corresponding negative likelihood ratio of 0.3.^23–26 Detecting a jugular venous pressure elevation of 12 cm results in a positive likelihood ratio of 10.4 and a negative likelihood ratio of 0.1 (Table 5).^23,24

In summary, an elevated jugular venous pressure on examination is a good test to rule in an elevated central venous pressure, and its absence is a good sign in ruling out an elevated central venous pressure. When using jugular venous pressure specifically for the diagnosis of congestive heart failure with reduced ejection fraction (ie, ejection fraction < 50%), the positive likelihood ratio is 6.3 based on 3 studies.^25–27

Heart failure with preserved ejection fraction has not been well studied for physical examination. The Irbesartan in Heart Failure with Preserved Ejection Fraction Trial (I-Preserve)²⁸ looked only at the sensitivity of elevated jugular venous pressure in 4,128 patients, which was 8%. Specificity was not reported.

The abdominojugular reflux

Another way to gauge the jugular venous pressure is to examine the neck veins while firmly pressing on the mid-abdomen for 10 to 15 seconds to look for the abdominojugular reflux, also known as the hepatojugular reflux. An increase in the jugular venous pressure of 3 cm from baseline constitutes a positive abdominojugular reflux. It has a positive likelihood ratio of 8.0 and a negative likelihood ratio of 0.3 for the diagnosis of congestive heart failure by the assessment of end-diastolic pressure of the left ventricle (Table 5).^29–31

The abdominojugular reflux is a much more reliable test than examination of neck veins for jugular venous pressure. The interobserver agreement for examining neck veins has a wide range of kappa scores (0.08–0.81), whereas the abdominojugular reflux has a very high kappa score of 0.92.⁷ Interestingly, chest radiography showing interstitial edema has a kappa of 0.83.⁷

Displaced apical impulse

An evaluation of the apical impulse of the heart is also a very good and quick test in the examination of patients suspected of having congestive heart failure. An abnormal finding is defined by an apical impulse displaced laterally (to the left of the midclavicular line).

Using data from several studies,^32–35 a displaced apical impulse has a positive likelihood ratio of 10.3. The absence of this finding, however, is not very good for ruling out congestive heart failure, with a negative likelihood ratio of 0.7. Interobserver agreement is moderate to excellent (kappa score 0.43–0.86).⁷

A third heart sound

Auscultation to assess the third heart sound is much more difficult. A systematic review found that likelihood ratios vary widely and confidence intervals are wide.³⁶ Interobserver agreement also varies widely (kappa scores –0.17 to 0.84).⁷ In a primary care study,³⁷ a third heart sound had a very low sensitivity (4.3%) but a specificity of 99.8%.

Therefore, we are uncertain about a conclusion for this physical finding based on the concern for wide ranges in likelihood ratio and poor interobserver reliability.

PHYSICAL EXAMINATION STILL HAS A FUTURE

The physical examination has a long and distinguished place in the history of medicine. Technologic advances have changed the manner in which clinicians practice the art of healing. Modern technology in US healthcare has become a double-edged sword, with many benefits as well as detriments.³ Reproducibility and accuracy are paramount for the physical examination to remain a core component of medical diagnosis. Advances in the diagnostic accuracy of laboratory and imaging studies challenge the importance of the physical examination. However, we firmly believe that the traditional techniques have stood the test of time and have a future in the clinical practice of medicine.

Acknowledgments: The authors thank Ruby Marr, MD, Mohammed Nabhan, MD, Rajiv Doddamani, MD, and Sohaib Galani, MD, for their important contributions to this article, which included research assistance and editorial advice.

Laennec’s stethoscope has survived more than 200 years, much longer than some of his contemporaries predicted. But will it survive the challenge of bedside ultrasonography and other technologic advances?

The physical examination, with its roots extending at least as far back as Hippocrates, may be at a crossroads as the mainstay of diagnosis. Physical signs can be subjective and lack sensitivity and specificity. Modern imaging and laboratory studies may already be more trusted.

If the physical examination is to survive, it must be accurate, reproducible, and efficient. Needed is a simple, evidence-based approach to the physical examination that enhances its diagnostic accuracy while maintaining bedside efficiency.

Here, we analyze the accuracy of the physical signs that are most effective in the clinical diagnosis of 4 common cardiopulmonary conditions that often present with dyspnea: pneumonia, pleural effusion, chronic obstructive pulmonary disease (COPD), and congestive heart failure.

LIKELIHOOD RATIOS

To grasp the significance of physical findings, it is necessary to understand the concept of likelihood ratios, which are widely accepted measures of the accuracy of a test or clinical finding.^1,2 The positive likelihood ratio is the probability of a disease being present when the test is positive or the clinical finding is present, while the negative likelihood ratio is the probability that the disease is present when the test is negative or the clinical finding is absent. They are calculated as follows¹:

Positive likelihood ratio = sensitivity / (1 – specificity)

Negative likelihood ratio = (1 – sensitivity) / specificity

Or more simply, they are calculated as the probability of the finding in patients with the disease, divided by the probability of the same finding in patients without the disease.² Thus, the higher the positive likelihood ratio, the greater the probability that a patient who has a positive finding actually has the disease. Conversely, the lower the negative likelihood ratio, the lower the probability that a person without the finding actually has the disease. A likelihood ratio of 1 means the test or finding is no better than chance.

Table 1 shows how the likelihood ratio of a test changes the posttest probability that a condition is present or absent, according to an analysis by McGee.²

STANDARDIZED TERMINOLOGY

The International Lung Sounds Association³ has proposed standard terminology for describing findings on chest auscultation, as the terminology used until now was considered imprecise. For simplicity, respiratory sounds can be described as either normal or abnormal (adventitious) (Table 2).⁴

PNEUMONIA

Pneumonia is a common disease, with more than 2 million cases annually in the United States. It is most often diagnosed by standard chest radiography, although computed tomography can identify it earlier and with higher sensitivity and specificity.⁵ The amount of published data on physical examination findings in pneumonia is surprisingly small.

Asymmetry in chest expansion: Specific, reproducible, but not sensitive

The physical finding with the highest positive likelihood ratio for diagnosing pneumonia is asymmetry in chest expansion.^6,7

From Diaz-Guzman E, Budev MM. Accuracy of the physical examination in evaluating pleural effusion. Cleve Clin J Med 2008; 75:297–303.

Chest expansion is typically examined posteriorly, with the thumbs placed together along the midline of the spine and the 4 fingers held together with the index finger below the 10th rib (Figure 1). As the patient takes a deep breath, the physician feels for asymmetric movement of his or her thumbs.

In a 1984 study of 1,819 patients presenting to an emergency department with acute cough, Diehr et al⁶ evaluated several physical signs of pneumonia. Asymmetric chest expansion had a specificity and positive predictive value of 100%, but its sensitivity was only 4.3%. Thus, it is not a good screening test, but it is a good diagnostic or confirmatory test. From these numbers, Metlay et al⁸ calculated that the positive likelihood ratio was infinity and the negative likelihood ratio was 0.96.

McGee,⁷ on the other hand, calculated the positive likelihood ratio of asymmetric chest expansion at 44.1. McGee also found chest expansion to be a highly reproducible finding, with an interobserver agreement kappa score of 0.85.⁷ (A kappa score of 1.0 would indicate perfect interobserver agreement.) Interestingly, chest radiographs interpreted for pulmonary infiltrates have an interobserver kappa score of only 0.38.⁷ Further studies of this physical sign could shed more light upon this area of uncertainty.

Other signs of pneumonia

None of the other physical signs studied for the diagnosis of pneumonia has as high a positive likelihood ratio as asymmetric chest expansion.^6–12

Egophony is a high-pitched or nasal quality of the patient’s voice heard on auscultation over lung tissue that is consolidated or fibrosed, due to enhanced transmission of high-frequency sound across fluid. It is often described as the “E-to-A change.” Although listening for egophony is widely done and easy to do, we calculate that this sign has a positive likelihood ratio of only 6.8 based on pooled data from 3 trials with a total of 3,245 patients.^6,10,11

Faring less favorably, in descending order of diagnostic accuracy, are:

Percussion dullness (positive likelihood ratio 5.7 based on 4 studies with 3,653 patients)^6,10–12

Bronchophony or bronchial breath sounds (positive likelihood ratio 3.3 based on 1,118 patients)¹⁰

Crackles have long been taught as a common physical finding in pneumonia. Bohadana et al pointed out that “crackle” can be defined acoustically but does not suggest any means or site of generation.⁴ Pooled data from 4 studies in 3,647 patients^6,10–12 result in a positive likelihood ratio for crackles in the diagnosis of pneumonia of only 3.2.

Diminished breath sounds (positive likelihood ratio 2.5 based on 3 studies with 1,828 patients).^10–12

 

 

Consider pneumonia signs in combination

These physical examination maneuvers are time-honored and part of the rite of training for medical students and residents. As we have shown, they are not extremely helpful as individual tests in diagnosing pneumonia; however, they may be useful when used in combination as a clinical prediction rule or diagnostic algorithm. These rules often have higher diagnostic accuracy but drawbacks of taking more time and not being easily reproducible.

None of these physical findings has a very low (clinically significant) negative likelihood ratio; therefore, their absence is not useful in ruling out pneumonia. The positive and negative likelihood ratios for these physical signs are summarized in Table 3.^6,9–14

PLEURAL EFFUSION

Pleural effusion commonly occurs in patients with congestive heart failure, pneumonia, and malignancies. The following are signs of effusion.

Dullness to percussion had a positive likelihood ratio of 5.7 from pooled data from 3 studies analyzed by Wong et al.¹³

Asymmetric chest expansion, in a study by Kalantri et al,¹⁴ had a positive likelihood ratio of 8.1 and a negative likelihood ratio of 0.29, the latter making it a reasonably good test to help rule out a pleural effusion.

Negative signs. Since a pleural effusion is an abnormal fluid collection in the pleural space and not the lung parenchyma, one would not expect it to cause loud breath sounds, adventitious sounds, or vocal resonance. Since these 3 findings emanate from the lung, their absence would be expected to support the presence of a pleural effusion.

Tactile fremitus, also known as vocal fremitus, is the vibration felt on the chest wall while the patient is speaking. Traditionally, the patient says “ninety-nine” as the examiner feels for asymmetry in vibration. A consolidation such as pneumonia increases the vibration, while fluid in a pleural effusion diminishes it.

To summarize, diminished breath sounds, diminished tactile fremitus, and diminished vocal resonance (either egophony or bronchophony) should support a diagnosis of a pleural effusion. As expected, the evidence supports these tests, which have very good negative likelihood ratios (Table 4).¹⁴ Tactile fremitus, loud breath sounds, or vocal resonance, if present, make pleural effusion very unlikely.

DIAGNOSTIC ALGORITHM FOR PNEUMONIA OR PLEURAL EFFUSION

Patients presenting with cough or dyspnea will most likely be evaluated for pneumonia and pleural effusion, among other diagnoses. We propose the following physical examination strategy in this setting.

First, evaluate the patient for asymmetric chest expansion. The positive likelihood ratio for this sign is excellent for pneumonia (44.1) and moderate for pleural effusion (8.1); therefore, both conditions are possible with a positive test.

Second, percuss the chest. Dullness to percussion has a low positive likelihood ratio for pneumonia but a moderate one for pleural effusion.¹³ The absence of this sign is only modest in excluding a pleural effusion (negative likelihood ratio 0.31 in pooled data analyzed by Wong et al).¹³

Third, auscultate the chest to elicit normal, diminished, or adventitious breath sounds. Diminished breath sounds may be noted in both conditions, but vocal resonance (egophony or bronchophony) and tactile fremitus should not be present directly over a pleural effusion. Either vocal resonance or tactile fremitus in a patient with asymmetric chest expansion would strongly support the diagnosis of pneumonia.

In a parapneumonic effusion or pneumonia with a concomitant empyema, a combination of findings may be present. In this case the pneumonia will be superior to the effusion and the characteristic findings for each should be present over the areas of disease in the lung.

Figure 2 summarizes our proposed diagnostic algorithm for pneumonia and pleural effusion.

CHRONIC OBSTRUCTIVE PULMONARY DISEASE

COPD imposes a heavy burden on public health worldwide in terms of cost and mortality. It is the third leading cause of death in the United States, after heart disease and cancer.¹⁵

Spirometry remains the gold standard for diagnosis. The Global Initiative for Chronic Obstructive Lung Disease standard for diagnosing COPD was the better of 2 spirometry test results, showing a forced expiratory volume in 1 second (FEV₁) and FEV₁/forced vital capacity ratio less than 70%.¹⁶

Unfortunately, there is little evidence that physical signs aid in the early diagnosis of COPD, as physical signs of airflow limitation may not manifest until lung function is substantially impaired.^17,18

Early inspiratory crackles had a positive likelihood ratio of 14.6 based on 2 small studies.^19,20

Percussion dullness over the left sternal border in the fifth intercostal space should be present in the normal situation and is known as cardiac dullness. Absent cardiac dullness had a positive likelihood ratio of 16 and a negative likelihood ratio of 0.8 for diagnosing COPD in a study in 92 patients with a history of smoking or self-reported COPD.²¹ The kappa score was 0.49, signifying moderate interobserver  agreement.

A combined strategy using the history and physical examination may have the highest diagnostic accuracy. Many of these combinations are too cumbersome for practical clinical use. However, 1 of them is based on only 3 questions²¹:

• Has the patient smoked for more than 70-pack years?
• Has the patient been previously diagnosed with chronic bronchitis or emphysema?
• Are breath sounds diminished in intensity?

Answering yes to 2 of these questions gives a positive likelihood ratio of a diagnosis of COPD of 33.5.

Early detection of COPD may improve outcomes and lower healthcare costs and thus would be clinically useful. Unfortunately, a diagnostic approach using the history and physical in the early diagnosis of COPD remains uncertain at this time.

 

 

CONGESTIVE HEART FAILURE

The clinical presentation of acute congestive heart failure has much in common with pneumonia, pleural effusion, and COPD.

Echocardiography, the gold standard for diagnosis, is costly and may not be immediately available for most patients evaluated for cardiorespiratory complaints. The American College of Cardiology reports the cost of standard echocardiography to be between $1,000 and $2,000.²² A physical examination approach in the assessment of dyspnea can be very useful.

Height of jugular venous distention approximates central venous pressure

Assessing the central venous pressure by estimating the vertical height of distention of the right internal or external jugular vein is validated and easily reproducible.^23,24 The use of the external jugular vein is supported by correlation with catheter-measured central venous pressure in critically ill patients.^25,26 The central venous pressure reflects the right atrial pressure, and in the absence of tricuspid stenosis, the right ventricular end-diastolic pressure. An elevation in central venous pressure can be seen in patients with congestive heart failure, pulmonary hypertension, and pulmonary valve stenosis.

The right side is preferred due to its anatomically direct route to the heart. In contrast, the left internal jugular vein crosses the mediastinum and can be compressed by the aorta, causing a false elevation.

Examination of the jugular venous pressure has good accuracy in the evaluation of elevated central venous pressure. Examination of the neck veins can detect a central venous pressure elevation of 8 cm with a positive likelihood ratio of 9.7 and a corresponding negative likelihood ratio of 0.3.^23–26 Detecting a jugular venous pressure elevation of 12 cm results in a positive likelihood ratio of 10.4 and a negative likelihood ratio of 0.1 (Table 5).^23,24

In summary, an elevated jugular venous pressure on examination is a good test to rule in an elevated central venous pressure, and its absence is a good sign in ruling out an elevated central venous pressure. When using jugular venous pressure specifically for the diagnosis of congestive heart failure with reduced ejection fraction (ie, ejection fraction < 50%), the positive likelihood ratio is 6.3 based on 3 studies.^25–27

Heart failure with preserved ejection fraction has not been well studied for physical examination. The Irbesartan in Heart Failure with Preserved Ejection Fraction Trial (I-Preserve)²⁸ looked only at the sensitivity of elevated jugular venous pressure in 4,128 patients, which was 8%. Specificity was not reported.

The abdominojugular reflux

Another way to gauge the jugular venous pressure is to examine the neck veins while firmly pressing on the mid-abdomen for 10 to 15 seconds to look for the abdominojugular reflux, also known as the hepatojugular reflux. An increase in the jugular venous pressure of 3 cm from baseline constitutes a positive abdominojugular reflux. It has a positive likelihood ratio of 8.0 and a negative likelihood ratio of 0.3 for the diagnosis of congestive heart failure by the assessment of end-diastolic pressure of the left ventricle (Table 5).^29–31

The abdominojugular reflux is a much more reliable test than examination of neck veins for jugular venous pressure. The interobserver agreement for examining neck veins has a wide range of kappa scores (0.08–0.81), whereas the abdominojugular reflux has a very high kappa score of 0.92.⁷ Interestingly, chest radiography showing interstitial edema has a kappa of 0.83.⁷

Displaced apical impulse

An evaluation of the apical impulse of the heart is also a very good and quick test in the examination of patients suspected of having congestive heart failure. An abnormal finding is defined by an apical impulse displaced laterally (to the left of the midclavicular line).

Using data from several studies,^32–35 a displaced apical impulse has a positive likelihood ratio of 10.3. The absence of this finding, however, is not very good for ruling out congestive heart failure, with a negative likelihood ratio of 0.7. Interobserver agreement is moderate to excellent (kappa score 0.43–0.86).⁷

A third heart sound

Auscultation to assess the third heart sound is much more difficult. A systematic review found that likelihood ratios vary widely and confidence intervals are wide.³⁶ Interobserver agreement also varies widely (kappa scores –0.17 to 0.84).⁷ In a primary care study,³⁷ a third heart sound had a very low sensitivity (4.3%) but a specificity of 99.8%.

Therefore, we are uncertain about a conclusion for this physical finding based on the concern for wide ranges in likelihood ratio and poor interobserver reliability.

PHYSICAL EXAMINATION STILL HAS A FUTURE

The physical examination has a long and distinguished place in the history of medicine. Technologic advances have changed the manner in which clinicians practice the art of healing. Modern technology in US healthcare has become a double-edged sword, with many benefits as well as detriments.³ Reproducibility and accuracy are paramount for the physical examination to remain a core component of medical diagnosis. Advances in the diagnostic accuracy of laboratory and imaging studies challenge the importance of the physical examination. However, we firmly believe that the traditional techniques have stood the test of time and have a future in the clinical practice of medicine.

Acknowledgments: The authors thank Ruby Marr, MD, Mohammed Nabhan, MD, Rajiv Doddamani, MD, and Sohaib Galani, MD, for their important contributions to this article, which included research assistance and editorial advice.