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Innovative Cosmeceuticals: Sirtuin Activators and Anti-Glycation Compounds
Patricia K. Farris, MD
Skin aging is a combination of natural aging with superimposed photoaging. Naturally aged skin is thin, fragile and finely wrinkled whereas photoaged skin is rough and thickened with deep coarse wrinkles. In addition photoaging is characterized by mottled pigmentation, solar lentigines, telangectasias and a loss of elasticity. The science behind skin aging has exploded in the past decade. Skin aging has now been defined on both a cellular and molecular level. The study of genomics in aging skin provides us with potential targets as points for intervention. In this regard, the science behind skin aging becomes a platform for the development of new anti-aging strategies and products. In this paper two new and emerging approaches to treat aging skin will be discussed. Sirtuin activating and antiglycation products are already being marketed by cosmetic and pharmaceutical companies. These anti-aging approaches are backed by basic science research and the ingredients used are supported by proof of concept studies although clinical trials are often lacking. It is this bench to beauty counter approach to cosmeceuticals that remains an industry standard today.
*For a PDF of the full article, click on the link to the left of this introduction.
Patricia K. Farris, MD
Skin aging is a combination of natural aging with superimposed photoaging. Naturally aged skin is thin, fragile and finely wrinkled whereas photoaged skin is rough and thickened with deep coarse wrinkles. In addition photoaging is characterized by mottled pigmentation, solar lentigines, telangectasias and a loss of elasticity. The science behind skin aging has exploded in the past decade. Skin aging has now been defined on both a cellular and molecular level. The study of genomics in aging skin provides us with potential targets as points for intervention. In this regard, the science behind skin aging becomes a platform for the development of new anti-aging strategies and products. In this paper two new and emerging approaches to treat aging skin will be discussed. Sirtuin activating and antiglycation products are already being marketed by cosmetic and pharmaceutical companies. These anti-aging approaches are backed by basic science research and the ingredients used are supported by proof of concept studies although clinical trials are often lacking. It is this bench to beauty counter approach to cosmeceuticals that remains an industry standard today.
*For a PDF of the full article, click on the link to the left of this introduction.
Patricia K. Farris, MD
Skin aging is a combination of natural aging with superimposed photoaging. Naturally aged skin is thin, fragile and finely wrinkled whereas photoaged skin is rough and thickened with deep coarse wrinkles. In addition photoaging is characterized by mottled pigmentation, solar lentigines, telangectasias and a loss of elasticity. The science behind skin aging has exploded in the past decade. Skin aging has now been defined on both a cellular and molecular level. The study of genomics in aging skin provides us with potential targets as points for intervention. In this regard, the science behind skin aging becomes a platform for the development of new anti-aging strategies and products. In this paper two new and emerging approaches to treat aging skin will be discussed. Sirtuin activating and antiglycation products are already being marketed by cosmetic and pharmaceutical companies. These anti-aging approaches are backed by basic science research and the ingredients used are supported by proof of concept studies although clinical trials are often lacking. It is this bench to beauty counter approach to cosmeceuticals that remains an industry standard today.
*For a PDF of the full article, click on the link to the left of this introduction.
Cosmeceuticals for Cellulite
Doris Hexsel, MD, and Mariana Soirefmann, MD, MSc
Cellulite is characterized by alterations to the skin surface, presenting as dimpled or puckered skin of the buttocks and posterior and lateral thighs. It mainly affects women. Cellulite occurrence is believed to be due to structural, inflammatory, morphological and biochemical alterations of the subcutaneous tissue. However, its pathogenesis is not completely understood. Topical treatments for cellulite include many agents, such those that increase the microcirculation flow, agents that reduce lipogenesis and promote lipolysis, agents that restore the normal structure of dermis and subcutaneous tissue, and agents that scavenge free radicals or prevent their formation. There are many cosmetic and medical treatments for cellulite. However, there is little clinical evidence of an improvement in cellulite, and none have been shown to lead to its resolution. The successful treatment of cellulite will ultimately depend upon our understanding of the physiopathology of cellulite adipose tissue.
*For a PDF of the full article, click on the link to the left of this introduction.
Doris Hexsel, MD, and Mariana Soirefmann, MD, MSc
Cellulite is characterized by alterations to the skin surface, presenting as dimpled or puckered skin of the buttocks and posterior and lateral thighs. It mainly affects women. Cellulite occurrence is believed to be due to structural, inflammatory, morphological and biochemical alterations of the subcutaneous tissue. However, its pathogenesis is not completely understood. Topical treatments for cellulite include many agents, such those that increase the microcirculation flow, agents that reduce lipogenesis and promote lipolysis, agents that restore the normal structure of dermis and subcutaneous tissue, and agents that scavenge free radicals or prevent their formation. There are many cosmetic and medical treatments for cellulite. However, there is little clinical evidence of an improvement in cellulite, and none have been shown to lead to its resolution. The successful treatment of cellulite will ultimately depend upon our understanding of the physiopathology of cellulite adipose tissue.
*For a PDF of the full article, click on the link to the left of this introduction.
Doris Hexsel, MD, and Mariana Soirefmann, MD, MSc
Cellulite is characterized by alterations to the skin surface, presenting as dimpled or puckered skin of the buttocks and posterior and lateral thighs. It mainly affects women. Cellulite occurrence is believed to be due to structural, inflammatory, morphological and biochemical alterations of the subcutaneous tissue. However, its pathogenesis is not completely understood. Topical treatments for cellulite include many agents, such those that increase the microcirculation flow, agents that reduce lipogenesis and promote lipolysis, agents that restore the normal structure of dermis and subcutaneous tissue, and agents that scavenge free radicals or prevent their formation. There are many cosmetic and medical treatments for cellulite. However, there is little clinical evidence of an improvement in cellulite, and none have been shown to lead to its resolution. The successful treatment of cellulite will ultimately depend upon our understanding of the physiopathology of cellulite adipose tissue.
*For a PDF of the full article, click on the link to the left of this introduction.
Treatment of Hyperpigmentation
Heather Woolery-Lloyd, MD, and Jenna N. Kammer, BA
Hyperpigmentation is a common dermatologic condition that is seen in all skin types but is most prominent in skin of color. In skin of color, any inflammation or injury to skin can almost immediately be accompanied by alterations in pigmentation, either hyperpigmentation or hypopigmentation. Post-inflammatory hyperpigmentation can be observed in many skin conditions including acne, eczema, and contact dermatitis and treatment can be challenging. The goal is to reduce the hyperpigmentation without causing undesirable hypopigmentation or irritation in the surrounding area. This review will discuss current research on treatments for hyperpigmentation and approaches to treating this condition.
*For a PDF of the full article, click on the link to the left of this introduction.
Heather Woolery-Lloyd, MD, and Jenna N. Kammer, BA
Hyperpigmentation is a common dermatologic condition that is seen in all skin types but is most prominent in skin of color. In skin of color, any inflammation or injury to skin can almost immediately be accompanied by alterations in pigmentation, either hyperpigmentation or hypopigmentation. Post-inflammatory hyperpigmentation can be observed in many skin conditions including acne, eczema, and contact dermatitis and treatment can be challenging. The goal is to reduce the hyperpigmentation without causing undesirable hypopigmentation or irritation in the surrounding area. This review will discuss current research on treatments for hyperpigmentation and approaches to treating this condition.
*For a PDF of the full article, click on the link to the left of this introduction.
Heather Woolery-Lloyd, MD, and Jenna N. Kammer, BA
Hyperpigmentation is a common dermatologic condition that is seen in all skin types but is most prominent in skin of color. In skin of color, any inflammation or injury to skin can almost immediately be accompanied by alterations in pigmentation, either hyperpigmentation or hypopigmentation. Post-inflammatory hyperpigmentation can be observed in many skin conditions including acne, eczema, and contact dermatitis and treatment can be challenging. The goal is to reduce the hyperpigmentation without causing undesirable hypopigmentation or irritation in the surrounding area. This review will discuss current research on treatments for hyperpigmentation and approaches to treating this condition.
*For a PDF of the full article, click on the link to the left of this introduction.
Nanotechnology Use with Cosmeceuticals
Nevenka Golubovic-Liakopoulos, PhD, Sanford R. Simon, PhD, and Bhavdeep Shah, PhD
The skin is a complex organ and its aging is a complex process. Cutaneous aging is influenced by factors such as sun exposure, genetics, stress and the environment. While skin laxity, rhytides, and dyschromia appear on the surface, these processes originate in deeper layers including the dermis and subcutaneous tissues. Until recently, most topical skin treatments were applied to, and consequently only affected the skin surface. Skin care has evolved to be scientifically based, and as knowledge increases about the physiology of the skin, novel methods of maintaining its health and appearance are developed. New generation skin care products are targeting multiple aging mechanisms by utilizing functional active ingredients in combination with innovative delivery systems.
*For a PDF of the full article, click on the link to the left of this introduction.
Nevenka Golubovic-Liakopoulos, PhD, Sanford R. Simon, PhD, and Bhavdeep Shah, PhD
The skin is a complex organ and its aging is a complex process. Cutaneous aging is influenced by factors such as sun exposure, genetics, stress and the environment. While skin laxity, rhytides, and dyschromia appear on the surface, these processes originate in deeper layers including the dermis and subcutaneous tissues. Until recently, most topical skin treatments were applied to, and consequently only affected the skin surface. Skin care has evolved to be scientifically based, and as knowledge increases about the physiology of the skin, novel methods of maintaining its health and appearance are developed. New generation skin care products are targeting multiple aging mechanisms by utilizing functional active ingredients in combination with innovative delivery systems.
*For a PDF of the full article, click on the link to the left of this introduction.
Nevenka Golubovic-Liakopoulos, PhD, Sanford R. Simon, PhD, and Bhavdeep Shah, PhD
The skin is a complex organ and its aging is a complex process. Cutaneous aging is influenced by factors such as sun exposure, genetics, stress and the environment. While skin laxity, rhytides, and dyschromia appear on the surface, these processes originate in deeper layers including the dermis and subcutaneous tissues. Until recently, most topical skin treatments were applied to, and consequently only affected the skin surface. Skin care has evolved to be scientifically based, and as knowledge increases about the physiology of the skin, novel methods of maintaining its health and appearance are developed. New generation skin care products are targeting multiple aging mechanisms by utilizing functional active ingredients in combination with innovative delivery systems.
*For a PDF of the full article, click on the link to the left of this introduction.
CO2 Laser Therapy in Dermatology and Dermatologic Surgery
Developing a Comprehensive Strategy for Aesthetic Rejuvenation
Procedural Options for Aging
Advantages and Disadvantages of 3-Dimensional Photography for Cosmetic Procedures [editorial]
Phototherapy in the Treatment of Cutaneous Herpesvirus Manifestations
Skin of Color: Nanotechnology Produces Appealing Sunscreens for Dark Skinned Patients
While the growing field of nanotechnology holds promise, particularly for darker skinned patients, it comes with its fair share of controversy.
Nanotechnology is the study of manipulating matter on a molecular scale by structuring ingredients into nanometer sized particles versus micrometer particles that are considerably larger.
The technology is currently being used in sunscreens, cosmetics, moisturizers, and anti-aging products because of properties that cannot be obtained using larger sized particles. In skin of color, nanotechnology has provided considerable benefit in the elegance of products, particularly sunscreens.
Chemical blockers in sunscreens, such as avobenzone, are greasy and difficult to blend. In addition, titanium dioxide leaves a white residue when applied to darker skin. When the ingredients are converted to nanoparticles, however, they are less greasy and leave the skin residue free while retaining their broad spectrum properties.
Because sunscreen use is much less prevalent in skin of color, particularly in black and Hispanic populations, skin cancer rates and photo-aging are on the rise in these populations. Although more educational and preventative health measures need to be undertaken, improvements in sunscreens may help drive use.
The safety of nanotechnology, however, has received considerable debate. Because the skin is the first line of defense, many dermatologists have concerns about the potential risk of nanotechnology.
Studies have shown that nanoparticles can enter skin with an altered integrity. Thus, products containing nanoparticles should never be used on damaged skin, burns, infants, and those with an inadequate skin barrier.
Considerable research on nanoparticles has shown that healthy, undamaged skin is an effective barrier for preventing the entry of nanoparticles into the deep layers of the dermis. And, the Food and Drug Administration’s Nanotechnology Task Force is currently investigating the safety of nanoparticles for skin care products because materials in the nano-scale dimension may have different chemical, physical, and biologic properties. The FDA has proposed guidelines for the use and development of nanotechnology to ensure patient safety and product efficacy.
Sunscreens are used to protect us from a known carcinogen: UV radiation. Nanoparticles have not been proven to be carcinogenic. In fact, sunscreens with nanoparticles have been shown to last longer, apply better to the skin, and provide better UVA and UVB protection than other products on the market.
We should encourage our skin of color patients that these products are safe and are more transparent than traditional products. This technology is providing more appealing products for us to offer our patients.
While the growing field of nanotechnology holds promise, particularly for darker skinned patients, it comes with its fair share of controversy.
Nanotechnology is the study of manipulating matter on a molecular scale by structuring ingredients into nanometer sized particles versus micrometer particles that are considerably larger.
The technology is currently being used in sunscreens, cosmetics, moisturizers, and anti-aging products because of properties that cannot be obtained using larger sized particles. In skin of color, nanotechnology has provided considerable benefit in the elegance of products, particularly sunscreens.
Chemical blockers in sunscreens, such as avobenzone, are greasy and difficult to blend. In addition, titanium dioxide leaves a white residue when applied to darker skin. When the ingredients are converted to nanoparticles, however, they are less greasy and leave the skin residue free while retaining their broad spectrum properties.
Because sunscreen use is much less prevalent in skin of color, particularly in black and Hispanic populations, skin cancer rates and photo-aging are on the rise in these populations. Although more educational and preventative health measures need to be undertaken, improvements in sunscreens may help drive use.
The safety of nanotechnology, however, has received considerable debate. Because the skin is the first line of defense, many dermatologists have concerns about the potential risk of nanotechnology.
Studies have shown that nanoparticles can enter skin with an altered integrity. Thus, products containing nanoparticles should never be used on damaged skin, burns, infants, and those with an inadequate skin barrier.
Considerable research on nanoparticles has shown that healthy, undamaged skin is an effective barrier for preventing the entry of nanoparticles into the deep layers of the dermis. And, the Food and Drug Administration’s Nanotechnology Task Force is currently investigating the safety of nanoparticles for skin care products because materials in the nano-scale dimension may have different chemical, physical, and biologic properties. The FDA has proposed guidelines for the use and development of nanotechnology to ensure patient safety and product efficacy.
Sunscreens are used to protect us from a known carcinogen: UV radiation. Nanoparticles have not been proven to be carcinogenic. In fact, sunscreens with nanoparticles have been shown to last longer, apply better to the skin, and provide better UVA and UVB protection than other products on the market.
We should encourage our skin of color patients that these products are safe and are more transparent than traditional products. This technology is providing more appealing products for us to offer our patients.
While the growing field of nanotechnology holds promise, particularly for darker skinned patients, it comes with its fair share of controversy.
Nanotechnology is the study of manipulating matter on a molecular scale by structuring ingredients into nanometer sized particles versus micrometer particles that are considerably larger.
The technology is currently being used in sunscreens, cosmetics, moisturizers, and anti-aging products because of properties that cannot be obtained using larger sized particles. In skin of color, nanotechnology has provided considerable benefit in the elegance of products, particularly sunscreens.
Chemical blockers in sunscreens, such as avobenzone, are greasy and difficult to blend. In addition, titanium dioxide leaves a white residue when applied to darker skin. When the ingredients are converted to nanoparticles, however, they are less greasy and leave the skin residue free while retaining their broad spectrum properties.
Because sunscreen use is much less prevalent in skin of color, particularly in black and Hispanic populations, skin cancer rates and photo-aging are on the rise in these populations. Although more educational and preventative health measures need to be undertaken, improvements in sunscreens may help drive use.
The safety of nanotechnology, however, has received considerable debate. Because the skin is the first line of defense, many dermatologists have concerns about the potential risk of nanotechnology.
Studies have shown that nanoparticles can enter skin with an altered integrity. Thus, products containing nanoparticles should never be used on damaged skin, burns, infants, and those with an inadequate skin barrier.
Considerable research on nanoparticles has shown that healthy, undamaged skin is an effective barrier for preventing the entry of nanoparticles into the deep layers of the dermis. And, the Food and Drug Administration’s Nanotechnology Task Force is currently investigating the safety of nanoparticles for skin care products because materials in the nano-scale dimension may have different chemical, physical, and biologic properties. The FDA has proposed guidelines for the use and development of nanotechnology to ensure patient safety and product efficacy.
Sunscreens are used to protect us from a known carcinogen: UV radiation. Nanoparticles have not been proven to be carcinogenic. In fact, sunscreens with nanoparticles have been shown to last longer, apply better to the skin, and provide better UVA and UVB protection than other products on the market.
We should encourage our skin of color patients that these products are safe and are more transparent than traditional products. This technology is providing more appealing products for us to offer our patients.