Drug Therapy

John D. Clough, MD
Editor in Chief

John D. Clough, MD
Editor in Chief

John D. Clough, MD
Editor in Chief

Andrea Sikon, MD
The Women’s Health Center at the Gault Women’s Health and Breast Pavilion, Department of General Internal Medicine, The Cleveland Clinic Foundation; Certified North American Menopause Society Menopause Clinician

Holly L. Thacker, MD
Director, The Women’s Health Center at the Gault Women’s Health and Breast Pavilion, Department of General Internal Medicine, and Department of Obstetrics and Gynecology, The Cleveland Clinic Foundation; Certified North American Menopause Society Menopause Clinician

Address: Holly L. Thacker, MD, FACP, Women’s Health Center at the Gault Women’s Health and Breast Pavilion, A10, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail thackeh@ccf.org

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

Andrea Sikon, MD
The Women’s Health Center at the Gault Women’s Health and Breast Pavilion, Department of General Internal Medicine, The Cleveland Clinic Foundation; Certified North American Menopause Society Menopause Clinician

Holly L. Thacker, MD
Director, The Women’s Health Center at the Gault Women’s Health and Breast Pavilion, Department of General Internal Medicine, and Department of Obstetrics and Gynecology, The Cleveland Clinic Foundation; Certified North American Menopause Society Menopause Clinician

Address: Holly L. Thacker, MD, FACP, Women’s Health Center at the Gault Women’s Health and Breast Pavilion, A10, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail thackeh@ccf.org

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

Andrea Sikon, MD
The Women’s Health Center at the Gault Women’s Health and Breast Pavilion, Department of General Internal Medicine, The Cleveland Clinic Foundation; Certified North American Menopause Society Menopause Clinician

Holly L. Thacker, MD
Director, The Women’s Health Center at the Gault Women’s Health and Breast Pavilion, Department of General Internal Medicine, and Department of Obstetrics and Gynecology, The Cleveland Clinic Foundation; Certified North American Menopause Society Menopause Clinician

Address: Holly L. Thacker, MD, FACP, Women’s Health Center at the Gault Women’s Health and Breast Pavilion, A10, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail thackeh@ccf.org

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

Shirley A. Bembo, MD
Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Stony Brook

Harold E. Carlson, MD
Professor, Department of Medicine, and Head, Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Stony Brook

Address: Shirley A. Bembo, MD, Division of Endocrinology and Metabolism, Health Sciences Center, T15 Room 060, Stony Brook University, Stony Brook, NY 11794-8154

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

Shirley A. Bembo, MD
Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Stony Brook

Harold E. Carlson, MD
Professor, Department of Medicine, and Head, Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Stony Brook

Address: Shirley A. Bembo, MD, Division of Endocrinology and Metabolism, Health Sciences Center, T15 Room 060, Stony Brook University, Stony Brook, NY 11794-8154

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

Shirley A. Bembo, MD
Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Stony Brook

Harold E. Carlson, MD
Professor, Department of Medicine, and Head, Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Stony Brook

Address: Shirley A. Bembo, MD, Division of Endocrinology and Metabolism, Health Sciences Center, T15 Room 060, Stony Brook University, Stony Brook, NY 11794-8154

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

G. Caleb Alexander, MD, MS
Robert Wood Johnson Clinical Scholars Program, MacLean Center for Clinical Medical Ethics, University of Chicago, Chicago, IL

Chien-Wen Tseng, MD, MPH
Pacific Health Research Institute; Department of Family Practice and Community Health, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI

Address: G. Caleb Alexander, MD, MS, RWJ Clinical Scholars Program, The University of Chicago, 5841 South Maryland, MC 2007, Chicago, IL 60637; e-mail galexand@uchicago.edu

The preparation of this manuscript was supported by the MacLean Center for Clinical Medical Ethics, University of Chicago.

G. Caleb Alexander, MD, MS
Robert Wood Johnson Clinical Scholars Program, MacLean Center for Clinical Medical Ethics, University of Chicago, Chicago, IL

Chien-Wen Tseng, MD, MPH
Pacific Health Research Institute; Department of Family Practice and Community Health, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI

Address: G. Caleb Alexander, MD, MS, RWJ Clinical Scholars Program, The University of Chicago, 5841 South Maryland, MC 2007, Chicago, IL 60637; e-mail galexand@uchicago.edu

The preparation of this manuscript was supported by the MacLean Center for Clinical Medical Ethics, University of Chicago.

G. Caleb Alexander, MD, MS
Robert Wood Johnson Clinical Scholars Program, MacLean Center for Clinical Medical Ethics, University of Chicago, Chicago, IL

Chien-Wen Tseng, MD, MPH
Pacific Health Research Institute; Department of Family Practice and Community Health, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI

Address: G. Caleb Alexander, MD, MS, RWJ Clinical Scholars Program, The University of Chicago, 5841 South Maryland, MC 2007, Chicago, IL 60637; e-mail galexand@uchicago.edu

The preparation of this manuscript was supported by the MacLean Center for Clinical Medical Ethics, University of Chicago.

Raul J. Seballos, MD
Section of Preventive Medicine, Department of General Internal Medicine, The Cleveland Clinic Foundation

James Gutierrez, MD
Department of General Internal Medicine, Division of Regional Medical Practice, The Cleveland Clinic Foundation

Address: Raul J. Seballos, MD, Section of Preventive Medicine, Department of General Internal Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland OH 44195; e-mail seballr@ccf.org

Raul J. Seballos, MD
Section of Preventive Medicine, Department of General Internal Medicine, The Cleveland Clinic Foundation

James Gutierrez, MD
Department of General Internal Medicine, Division of Regional Medical Practice, The Cleveland Clinic Foundation

Address: Raul J. Seballos, MD, Section of Preventive Medicine, Department of General Internal Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland OH 44195; e-mail seballr@ccf.org

Raul J. Seballos, MD
Section of Preventive Medicine, Department of General Internal Medicine, The Cleveland Clinic Foundation

James Gutierrez, MD
Department of General Internal Medicine, Division of Regional Medical Practice, The Cleveland Clinic Foundation

Address: Raul J. Seballos, MD, Section of Preventive Medicine, Department of General Internal Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland OH 44195; e-mail seballr@ccf.org

Michael E. Weinblatt, MD
Co-director of Clinical Rheumatology, Brigham and Women’s Hospital; Professor of Medicine, Harvard Medical School, Boston, MA

Address: Michael E. Weinblatt, MD, Brigham and Women’s Hospital, Rheumatology-Immunology-Allergy, Arthritis Center, 75 Francis Street, Boston, MA 02115

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

The author has indicated that he has received grant or research support from the Abbott, Amgen, Bristol-Myers Squibb, and Millennium companies and has served as a consultant for Abbott, Amgen, Bristol-Myers Squibb, Centocor, Genentech, Merck, Millennium, Roche, TAP, and Wyeth.

This paper discusses therapies that are investigational or are not approved by the US Food and Drug Administration for the use under discussion.

Michael E. Weinblatt, MD
Co-director of Clinical Rheumatology, Brigham and Women’s Hospital; Professor of Medicine, Harvard Medical School, Boston, MA

Address: Michael E. Weinblatt, MD, Brigham and Women’s Hospital, Rheumatology-Immunology-Allergy, Arthritis Center, 75 Francis Street, Boston, MA 02115

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

The author has indicated that he has received grant or research support from the Abbott, Amgen, Bristol-Myers Squibb, and Millennium companies and has served as a consultant for Abbott, Amgen, Bristol-Myers Squibb, Centocor, Genentech, Merck, Millennium, Roche, TAP, and Wyeth.

This paper discusses therapies that are investigational or are not approved by the US Food and Drug Administration for the use under discussion.

Michael E. Weinblatt, MD
Co-director of Clinical Rheumatology, Brigham and Women’s Hospital; Professor of Medicine, Harvard Medical School, Boston, MA

Address: Michael E. Weinblatt, MD, Brigham and Women’s Hospital, Rheumatology-Immunology-Allergy, Arthritis Center, 75 Francis Street, Boston, MA 02115

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

The author has indicated that he has received grant or research support from the Abbott, Amgen, Bristol-Myers Squibb, and Millennium companies and has served as a consultant for Abbott, Amgen, Bristol-Myers Squibb, Centocor, Genentech, Merck, Millennium, Roche, TAP, and Wyeth.

This paper discusses therapies that are investigational or are not approved by the US Food and Drug Administration for the use under discussion.

Pasquale J. Palumbo, MD
Mayo Clinic Scottsdale, Scottsdale, AZ

Address: Pasquale J. Palumbo, MD, Mayo Clinic Scottsdale, 13400 East Shea Boulevard, Scottsdale, AZ 85259; e-mail palumbo.pasquale@mayo.edu

The preparation of this manuscript was supported in part by an unrestricted educational grant from Aventis Pharmaceuticals. This article discusses therapies that are not yet approved by the US Food and Drug Administration for the use under discusion.

Pasquale J. Palumbo, MD
Mayo Clinic Scottsdale, Scottsdale, AZ

Address: Pasquale J. Palumbo, MD, Mayo Clinic Scottsdale, 13400 East Shea Boulevard, Scottsdale, AZ 85259; e-mail palumbo.pasquale@mayo.edu

The preparation of this manuscript was supported in part by an unrestricted educational grant from Aventis Pharmaceuticals. This article discusses therapies that are not yet approved by the US Food and Drug Administration for the use under discusion.

Pasquale J. Palumbo, MD
Mayo Clinic Scottsdale, Scottsdale, AZ

Address: Pasquale J. Palumbo, MD, Mayo Clinic Scottsdale, 13400 East Shea Boulevard, Scottsdale, AZ 85259; e-mail palumbo.pasquale@mayo.edu

The preparation of this manuscript was supported in part by an unrestricted educational grant from Aventis Pharmaceuticals. This article discusses therapies that are not yet approved by the US Food and Drug Administration for the use under discusion.