Clinical question: How can the model for end-stage liver disease (MELD)-based model be updated and utilized to predict inpatient mortality rates of hospitalized cirrhotic patients with acute variceal bleeding (AVB)?

Background: AVB in cirrhosis continues to carry mortality rates as high as 20%. Risk prediction for individual patients is important to determine when a step-up in acuity of care is needed and to identify patients who would most benefit from preemptive treatments such as a transjugular intrahepatic portosystemic shunt. Many predictive models are available but are currently difficult to apply in the clinical setting.

Study design: Initial comparison data was collected via a prospective study from clinical records. Confirmation of updated MELD model occurred via cohort validation studies.

Setting: Prospective data collected from Hospital Clinic in Barcelona, Spain. Validation cohorts for new MELD model calibration completed in hospital settings in Canada and Spain.

Synopsis: Data was collected from 178 patients with cirrhosis and esophageal AVB receiving standard therapy from 2007-2010. Esophageal bleeding was confirmed endoscopically. The primary endpoint was six-week, bleeding-related mortality. Among all the subjects studied, the average six-week mortality rate was 16%. Models evaluated for validity included the Child-Pugh, the D’Amico and Augustin models, and the MELD score.

Each model was assessed via discrimination, calibration, and overall performance in mortality prediction. The MELD was identified as the best model in terms of discrimination and overall performance but was miscalibrated. The original validation cohort from the Hospital Clinic in Spain was utilized to update the MELD calibration via logistic regression. External validation was completed via cohort studies in Canada (N=240) and at Vall D’Hebron Hospital in Spain (N=221).

Using the updated model, the MELD score adds a predictive component in the setting of AVB that has not been available. MELD values of 19 and higher predict mortality >20%, whereas MELD values lower than 11 predict mortality of 5%.

Bottom line: Utilization of the updated MELD model may provide a more accurate method to identify patients in which more aggressive preemptive therapies are indicated using prognostic predictions of mortality.

Citation: Reverter E, Tandon P, Augustin S, et al. A MELD-based model to determine risk of mortality among patients with acute variceal bleeding. Gastroenterology. 2014;146(2):412-419.

Clinical question: How can the model for end-stage liver disease (MELD)-based model be updated and utilized to predict inpatient mortality rates of hospitalized cirrhotic patients with acute variceal bleeding (AVB)?

Background: AVB in cirrhosis continues to carry mortality rates as high as 20%. Risk prediction for individual patients is important to determine when a step-up in acuity of care is needed and to identify patients who would most benefit from preemptive treatments such as a transjugular intrahepatic portosystemic shunt. Many predictive models are available but are currently difficult to apply in the clinical setting.

Study design: Initial comparison data was collected via a prospective study from clinical records. Confirmation of updated MELD model occurred via cohort validation studies.

Setting: Prospective data collected from Hospital Clinic in Barcelona, Spain. Validation cohorts for new MELD model calibration completed in hospital settings in Canada and Spain.

Synopsis: Data was collected from 178 patients with cirrhosis and esophageal AVB receiving standard therapy from 2007-2010. Esophageal bleeding was confirmed endoscopically. The primary endpoint was six-week, bleeding-related mortality. Among all the subjects studied, the average six-week mortality rate was 16%. Models evaluated for validity included the Child-Pugh, the D’Amico and Augustin models, and the MELD score.

Each model was assessed via discrimination, calibration, and overall performance in mortality prediction. The MELD was identified as the best model in terms of discrimination and overall performance but was miscalibrated. The original validation cohort from the Hospital Clinic in Spain was utilized to update the MELD calibration via logistic regression. External validation was completed via cohort studies in Canada (N=240) and at Vall D’Hebron Hospital in Spain (N=221).

Using the updated model, the MELD score adds a predictive component in the setting of AVB that has not been available. MELD values of 19 and higher predict mortality >20%, whereas MELD values lower than 11 predict mortality of 5%.

Bottom line: Utilization of the updated MELD model may provide a more accurate method to identify patients in which more aggressive preemptive therapies are indicated using prognostic predictions of mortality.

Citation: Reverter E, Tandon P, Augustin S, et al. A MELD-based model to determine risk of mortality among patients with acute variceal bleeding. Gastroenterology. 2014;146(2):412-419.

Clinical question: How can the model for end-stage liver disease (MELD)-based model be updated and utilized to predict inpatient mortality rates of hospitalized cirrhotic patients with acute variceal bleeding (AVB)?

Background: AVB in cirrhosis continues to carry mortality rates as high as 20%. Risk prediction for individual patients is important to determine when a step-up in acuity of care is needed and to identify patients who would most benefit from preemptive treatments such as a transjugular intrahepatic portosystemic shunt. Many predictive models are available but are currently difficult to apply in the clinical setting.

Study design: Initial comparison data was collected via a prospective study from clinical records. Confirmation of updated MELD model occurred via cohort validation studies.

Setting: Prospective data collected from Hospital Clinic in Barcelona, Spain. Validation cohorts for new MELD model calibration completed in hospital settings in Canada and Spain.

Synopsis: Data was collected from 178 patients with cirrhosis and esophageal AVB receiving standard therapy from 2007-2010. Esophageal bleeding was confirmed endoscopically. The primary endpoint was six-week, bleeding-related mortality. Among all the subjects studied, the average six-week mortality rate was 16%. Models evaluated for validity included the Child-Pugh, the D’Amico and Augustin models, and the MELD score.

Each model was assessed via discrimination, calibration, and overall performance in mortality prediction. The MELD was identified as the best model in terms of discrimination and overall performance but was miscalibrated. The original validation cohort from the Hospital Clinic in Spain was utilized to update the MELD calibration via logistic regression. External validation was completed via cohort studies in Canada (N=240) and at Vall D’Hebron Hospital in Spain (N=221).

Using the updated model, the MELD score adds a predictive component in the setting of AVB that has not been available. MELD values of 19 and higher predict mortality >20%, whereas MELD values lower than 11 predict mortality of 5%.

Bottom line: Utilization of the updated MELD model may provide a more accurate method to identify patients in which more aggressive preemptive therapies are indicated using prognostic predictions of mortality.

Citation: Reverter E, Tandon P, Augustin S, et al. A MELD-based model to determine risk of mortality among patients with acute variceal bleeding. Gastroenterology. 2014;146(2):412-419.

Clinical question: What is the national burden of ED visits and hospitalizations for insulin-related hypoglycemia?

Background: As the prevalence of diabetes mellitus continues to rise, the use of insulin and the burden of insulin-related hypoglycemia on our healthcare system will increase. By identifying high-risk populations and analyzing the circumstances of insulin-related hypoglycemia, we might be able to identify and employ strategies to decrease the risk of insulin use.

Study design: Observational study using national adverse drug surveillance database and national household survey.

Setting: U.S. hospitals, excluding psychiatric and penal institutions.

Synopsis: Using data from the National Electronic Injury Surveillance System–Cooperative Adverse Drug Event Surveillance (NEISS-CADES) Project and the National Health Interview Survey (NHIS), the authors estimated the rates and characteristics of ED visits and hospitalizations for insulin-related hypoglycemia. The authors estimated that about 100,000 ED visits occur nationally and that almost one-third of those visits result in hospitalization. Compared to younger patients treated with insulin, patients 80 years or older were more likely to present to the ED (rate ratio, 2.5; 95% CI, 1.5-4.3) and much more likely to be subsequently hospitalized (rate ratio, 4.9; 95% CI, 2.6-9.1) for insulin-related hypoglycemia.

The most common causes of insulin-induced hypoglycemia were failure to reduce insulin during periods of reduced food intake and confusion between short-acting and long-acting insulin. The authors suggest that looser glycemic control be sought in elderly patients to decrease the risk of insulin-related hypoglycemia and subsequent sequelae. Patient education addressing common insulin errors might also decrease the burden of ED visits and hospitalizations related to insulin.

Bottom line: Risks of hypoglycemia in patients older than 80 should be considered prior to starting an insulin regimen or prior to increasing the dose of insulin.

Citation: Geller AI, Shehab N, Lovegrove MC, et al. National estimates of insulin-related hypoglycemia and errors leading to emergency department visits and hospitalizations. JAMA Intern Med. 2014;174(5):678-686.

Clinical question: What is the national burden of ED visits and hospitalizations for insulin-related hypoglycemia?

Background: As the prevalence of diabetes mellitus continues to rise, the use of insulin and the burden of insulin-related hypoglycemia on our healthcare system will increase. By identifying high-risk populations and analyzing the circumstances of insulin-related hypoglycemia, we might be able to identify and employ strategies to decrease the risk of insulin use.

Study design: Observational study using national adverse drug surveillance database and national household survey.

Setting: U.S. hospitals, excluding psychiatric and penal institutions.

Synopsis: Using data from the National Electronic Injury Surveillance System–Cooperative Adverse Drug Event Surveillance (NEISS-CADES) Project and the National Health Interview Survey (NHIS), the authors estimated the rates and characteristics of ED visits and hospitalizations for insulin-related hypoglycemia. The authors estimated that about 100,000 ED visits occur nationally and that almost one-third of those visits result in hospitalization. Compared to younger patients treated with insulin, patients 80 years or older were more likely to present to the ED (rate ratio, 2.5; 95% CI, 1.5-4.3) and much more likely to be subsequently hospitalized (rate ratio, 4.9; 95% CI, 2.6-9.1) for insulin-related hypoglycemia.

The most common causes of insulin-induced hypoglycemia were failure to reduce insulin during periods of reduced food intake and confusion between short-acting and long-acting insulin. The authors suggest that looser glycemic control be sought in elderly patients to decrease the risk of insulin-related hypoglycemia and subsequent sequelae. Patient education addressing common insulin errors might also decrease the burden of ED visits and hospitalizations related to insulin.

Bottom line: Risks of hypoglycemia in patients older than 80 should be considered prior to starting an insulin regimen or prior to increasing the dose of insulin.

Citation: Geller AI, Shehab N, Lovegrove MC, et al. National estimates of insulin-related hypoglycemia and errors leading to emergency department visits and hospitalizations. JAMA Intern Med. 2014;174(5):678-686.

Clinical question: What is the national burden of ED visits and hospitalizations for insulin-related hypoglycemia?

Background: As the prevalence of diabetes mellitus continues to rise, the use of insulin and the burden of insulin-related hypoglycemia on our healthcare system will increase. By identifying high-risk populations and analyzing the circumstances of insulin-related hypoglycemia, we might be able to identify and employ strategies to decrease the risk of insulin use.

Study design: Observational study using national adverse drug surveillance database and national household survey.

Setting: U.S. hospitals, excluding psychiatric and penal institutions.

Synopsis: Using data from the National Electronic Injury Surveillance System–Cooperative Adverse Drug Event Surveillance (NEISS-CADES) Project and the National Health Interview Survey (NHIS), the authors estimated the rates and characteristics of ED visits and hospitalizations for insulin-related hypoglycemia. The authors estimated that about 100,000 ED visits occur nationally and that almost one-third of those visits result in hospitalization. Compared to younger patients treated with insulin, patients 80 years or older were more likely to present to the ED (rate ratio, 2.5; 95% CI, 1.5-4.3) and much more likely to be subsequently hospitalized (rate ratio, 4.9; 95% CI, 2.6-9.1) for insulin-related hypoglycemia.

The most common causes of insulin-induced hypoglycemia were failure to reduce insulin during periods of reduced food intake and confusion between short-acting and long-acting insulin. The authors suggest that looser glycemic control be sought in elderly patients to decrease the risk of insulin-related hypoglycemia and subsequent sequelae. Patient education addressing common insulin errors might also decrease the burden of ED visits and hospitalizations related to insulin.

Bottom line: Risks of hypoglycemia in patients older than 80 should be considered prior to starting an insulin regimen or prior to increasing the dose of insulin.

Citation: Geller AI, Shehab N, Lovegrove MC, et al. National estimates of insulin-related hypoglycemia and errors leading to emergency department visits and hospitalizations. JAMA Intern Med. 2014;174(5):678-686.

Clinical question: What are the perceptions of patients and healthcare personnel (HCP) regarding attire, and what evidence exists for contamination and transmission of pathogenic microorganisms by HCP attire?

Background: HCP attire is an important aspect of the healthcare profession. There is increasing concern for microorganism transmission in the hospital by fomites, including HCP apparel, and studies demonstrate contamination of HCP apparel; however, there is a lack of evidence demonstrating the role of HCP apparel in transmission of microorganisms to patients.

Study design: Literature and policy review, survey of Society for Healthcare Epidemiology of America (SHEA) members.

Setting: Literature search from January 2013 to March 2013 for articles related to bacterial contamination and laundering of HCP attire and patient and provider perceptions of HCP attire and/or footwear. Review of policies related to HCP attire from seven large teaching hospitals.

Synopsis: The search identified 26 articles that studied patients’ perceptions of HCP attire and only four studies that reviewed HCP preferences relating to attire. There were 11 small prospective studies related to pathogen contamination of HCP apparel but no clinical studies demonstrating transmission of pathogens from HCP attire to patients. There was one report of a pathogen outbreak potentially related to HCP apparel.

Hospital policies primarily related to general appearance and dress for all employees without significant specifications for HCP outside of sterile or procedure-based areas. One institution recommended bare below the elbows (BBE) attire for physicians during patient care activities.

There were 337 responses (21.7% response rate) to the survey, which showed poor enforcement of HCP attire policies, but a majority of respondents felt that the role of HCP attire in the transmission of pathogens in the healthcare setting was very important or somewhat important.

Patients preferred formal attire, including a white coat, but this preference had limited impact on patient satisfaction or confidence in practitioners. Patients did not perceive HCP attire as an infection risk but were willing to change their preference for formal attire when informed of this potential risk.

BBE policies are in effect at some U.S. hospitals and in the United Kingdom, but the effect on healthcare-associated infection rates and transmission of pathogens to patients is unknown.

Bottom line: Contamination of HCP attire with healthcare pathogens occurs, but no clinical data currently exists related to transmission of these pathogens to patients and its impact on the healthcare system. Patient satisfaction and confidence are not affected by less formal attire when informed of potential infection risks.

Citation: Bearman G, Bryant K, Leekha S, et al. Healthcare personnel attire in non-operating-room settings. Infect Control Hosp Epidemiol. 2014;35(2):107-121.

Clinical question: What are the perceptions of patients and healthcare personnel (HCP) regarding attire, and what evidence exists for contamination and transmission of pathogenic microorganisms by HCP attire?

Background: HCP attire is an important aspect of the healthcare profession. There is increasing concern for microorganism transmission in the hospital by fomites, including HCP apparel, and studies demonstrate contamination of HCP apparel; however, there is a lack of evidence demonstrating the role of HCP apparel in transmission of microorganisms to patients.

Study design: Literature and policy review, survey of Society for Healthcare Epidemiology of America (SHEA) members.

Setting: Literature search from January 2013 to March 2013 for articles related to bacterial contamination and laundering of HCP attire and patient and provider perceptions of HCP attire and/or footwear. Review of policies related to HCP attire from seven large teaching hospitals.

Synopsis: The search identified 26 articles that studied patients’ perceptions of HCP attire and only four studies that reviewed HCP preferences relating to attire. There were 11 small prospective studies related to pathogen contamination of HCP apparel but no clinical studies demonstrating transmission of pathogens from HCP attire to patients. There was one report of a pathogen outbreak potentially related to HCP apparel.

Hospital policies primarily related to general appearance and dress for all employees without significant specifications for HCP outside of sterile or procedure-based areas. One institution recommended bare below the elbows (BBE) attire for physicians during patient care activities.

There were 337 responses (21.7% response rate) to the survey, which showed poor enforcement of HCP attire policies, but a majority of respondents felt that the role of HCP attire in the transmission of pathogens in the healthcare setting was very important or somewhat important.

Patients preferred formal attire, including a white coat, but this preference had limited impact on patient satisfaction or confidence in practitioners. Patients did not perceive HCP attire as an infection risk but were willing to change their preference for formal attire when informed of this potential risk.

BBE policies are in effect at some U.S. hospitals and in the United Kingdom, but the effect on healthcare-associated infection rates and transmission of pathogens to patients is unknown.

Bottom line: Contamination of HCP attire with healthcare pathogens occurs, but no clinical data currently exists related to transmission of these pathogens to patients and its impact on the healthcare system. Patient satisfaction and confidence are not affected by less formal attire when informed of potential infection risks.

Citation: Bearman G, Bryant K, Leekha S, et al. Healthcare personnel attire in non-operating-room settings. Infect Control Hosp Epidemiol. 2014;35(2):107-121.

Clinical question: What are the perceptions of patients and healthcare personnel (HCP) regarding attire, and what evidence exists for contamination and transmission of pathogenic microorganisms by HCP attire?

Background: HCP attire is an important aspect of the healthcare profession. There is increasing concern for microorganism transmission in the hospital by fomites, including HCP apparel, and studies demonstrate contamination of HCP apparel; however, there is a lack of evidence demonstrating the role of HCP apparel in transmission of microorganisms to patients.

Study design: Literature and policy review, survey of Society for Healthcare Epidemiology of America (SHEA) members.

Setting: Literature search from January 2013 to March 2013 for articles related to bacterial contamination and laundering of HCP attire and patient and provider perceptions of HCP attire and/or footwear. Review of policies related to HCP attire from seven large teaching hospitals.

Synopsis: The search identified 26 articles that studied patients’ perceptions of HCP attire and only four studies that reviewed HCP preferences relating to attire. There were 11 small prospective studies related to pathogen contamination of HCP apparel but no clinical studies demonstrating transmission of pathogens from HCP attire to patients. There was one report of a pathogen outbreak potentially related to HCP apparel.

Hospital policies primarily related to general appearance and dress for all employees without significant specifications for HCP outside of sterile or procedure-based areas. One institution recommended bare below the elbows (BBE) attire for physicians during patient care activities.

There were 337 responses (21.7% response rate) to the survey, which showed poor enforcement of HCP attire policies, but a majority of respondents felt that the role of HCP attire in the transmission of pathogens in the healthcare setting was very important or somewhat important.

Patients preferred formal attire, including a white coat, but this preference had limited impact on patient satisfaction or confidence in practitioners. Patients did not perceive HCP attire as an infection risk but were willing to change their preference for formal attire when informed of this potential risk.

BBE policies are in effect at some U.S. hospitals and in the United Kingdom, but the effect on healthcare-associated infection rates and transmission of pathogens to patients is unknown.

Bottom line: Contamination of HCP attire with healthcare pathogens occurs, but no clinical data currently exists related to transmission of these pathogens to patients and its impact on the healthcare system. Patient satisfaction and confidence are not affected by less formal attire when informed of potential infection risks.

Citation: Bearman G, Bryant K, Leekha S, et al. Healthcare personnel attire in non-operating-room settings. Infect Control Hosp Epidemiol. 2014;35(2):107-121.

Clinical question: What are the risk factors associated with potentially avoidable readmissions (PARs) for end-of-life care issues?

Background: The 6% of Medicare beneficiaries who die each year account for 30% of yearly Medicare expenditures on medical treatments, with repeated hospitalizations a frequent occurrence at the end of life. There are many opportunities to improve the care of patients at the end of life.

Study design: Nested case-control.

Setting: Academic, tertiary-care medical center.

Synopsis: There were 10,275 eligible admissions to Brigham and Women’s Hospital in Boston from July 1, 2009 to June 30, 2010, with a length of stay less than one day. There were 2,301 readmissions within 30 days of the index hospitalization, of which 826 were considered potentially avoidable. From a random sample of 594 of these patients, 80 patients had PAR related to end-of-life care issues. There were 7,974 patients who were not admitted within 30 days of index admission (controls). The primary study outcome was any 30-day PAR due to end-of-life care issues. A readmission was considered a PAR if it related to previously known conditions from the index hospitalization or was due to a complication of treatment.

The four factors that were significantly associated with 30-day PAR for end-of-life care issues were: neoplasm (OR 5.6, 95% CI: 2.85-11.0), opiate medication at discharge (OR 2.29, 95% CI: 1.29-4.07), Elixhauser comorbidity index, per five-unit increase (OR 1.16, 95% CI: 1.10-1.22), and number of admissions in previous 12 months (OR 1.10, 95% CI: 1.02-1.20). The model that included all four variables had excellent discrimination power, with a C-statistic of 0.85.

Bottom line: The factors from this prediction model can be used, formally or informally, to identify those patients at higher risk for readmission for end-of-life care issues and prioritize resources to help minimize this risk.

Citation: Donzé J, Lipsitz S, Schnipper JL. Risk factors for potentially avoidable readmissions due to end-of-life care issues. J Hosp Med. 2014;9(5):310-314.

Clinical question: What are the risk factors associated with potentially avoidable readmissions (PARs) for end-of-life care issues?

Background: The 6% of Medicare beneficiaries who die each year account for 30% of yearly Medicare expenditures on medical treatments, with repeated hospitalizations a frequent occurrence at the end of life. There are many opportunities to improve the care of patients at the end of life.

Study design: Nested case-control.

Setting: Academic, tertiary-care medical center.

Synopsis: There were 10,275 eligible admissions to Brigham and Women’s Hospital in Boston from July 1, 2009 to June 30, 2010, with a length of stay less than one day. There were 2,301 readmissions within 30 days of the index hospitalization, of which 826 were considered potentially avoidable. From a random sample of 594 of these patients, 80 patients had PAR related to end-of-life care issues. There were 7,974 patients who were not admitted within 30 days of index admission (controls). The primary study outcome was any 30-day PAR due to end-of-life care issues. A readmission was considered a PAR if it related to previously known conditions from the index hospitalization or was due to a complication of treatment.

The four factors that were significantly associated with 30-day PAR for end-of-life care issues were: neoplasm (OR 5.6, 95% CI: 2.85-11.0), opiate medication at discharge (OR 2.29, 95% CI: 1.29-4.07), Elixhauser comorbidity index, per five-unit increase (OR 1.16, 95% CI: 1.10-1.22), and number of admissions in previous 12 months (OR 1.10, 95% CI: 1.02-1.20). The model that included all four variables had excellent discrimination power, with a C-statistic of 0.85.

Bottom line: The factors from this prediction model can be used, formally or informally, to identify those patients at higher risk for readmission for end-of-life care issues and prioritize resources to help minimize this risk.

Citation: Donzé J, Lipsitz S, Schnipper JL. Risk factors for potentially avoidable readmissions due to end-of-life care issues. J Hosp Med. 2014;9(5):310-314.

Clinical question: What are the risk factors associated with potentially avoidable readmissions (PARs) for end-of-life care issues?

Background: The 6% of Medicare beneficiaries who die each year account for 30% of yearly Medicare expenditures on medical treatments, with repeated hospitalizations a frequent occurrence at the end of life. There are many opportunities to improve the care of patients at the end of life.

Study design: Nested case-control.

Setting: Academic, tertiary-care medical center.

Synopsis: There were 10,275 eligible admissions to Brigham and Women’s Hospital in Boston from July 1, 2009 to June 30, 2010, with a length of stay less than one day. There were 2,301 readmissions within 30 days of the index hospitalization, of which 826 were considered potentially avoidable. From a random sample of 594 of these patients, 80 patients had PAR related to end-of-life care issues. There were 7,974 patients who were not admitted within 30 days of index admission (controls). The primary study outcome was any 30-day PAR due to end-of-life care issues. A readmission was considered a PAR if it related to previously known conditions from the index hospitalization or was due to a complication of treatment.

The four factors that were significantly associated with 30-day PAR for end-of-life care issues were: neoplasm (OR 5.6, 95% CI: 2.85-11.0), opiate medication at discharge (OR 2.29, 95% CI: 1.29-4.07), Elixhauser comorbidity index, per five-unit increase (OR 1.16, 95% CI: 1.10-1.22), and number of admissions in previous 12 months (OR 1.10, 95% CI: 1.02-1.20). The model that included all four variables had excellent discrimination power, with a C-statistic of 0.85.

Bottom line: The factors from this prediction model can be used, formally or informally, to identify those patients at higher risk for readmission for end-of-life care issues and prioritize resources to help minimize this risk.

Citation: Donzé J, Lipsitz S, Schnipper JL. Risk factors for potentially avoidable readmissions due to end-of-life care issues. J Hosp Med. 2014;9(5):310-314.

Clinical question: What is the benefit of routine colonic evaluation after an episode of acute diverticulitis?

Background: Currently accepted guidelines recommend routine colonic evaluation (colonoscopy, computed tomography (CT) colonography) after an episode of acute diverticulitis to confirm the diagnosis and exclude malignancy. Increased use of CT to confirm the diagnosis of acute diverticulitis and exclude associated complications has brought into question the recommendation for routine colonic evaluation after an episode of acute diverticulitis.

Study design: Meta-analysis.

Setting: Search of online databases and the Cochrane Library.

Synopsis: Eleven studies from seven countries included 1,970 patients who had a colonic evaluation after an episode of acute diverticulitis. The risk of finding a malignancy was 1.6%. Within this population, 1,497 patients were identified as having uncomplicated diverticulitis. Cancer was found in only five patients (proportional risk estimate 0.7%).

For the 79 patients identified as having complicated diverticulitis, the risk of finding a malignancy on subsequent screening was 10.8%.

Every systematic review is limited by the quality of the studies available for review and the differences in design and methodology of the studies. In this meta-analysis, the risk of finding cancer after an episode of uncomplicated diverticulitis appears to be low. Given the limited resources of the healthcare system and the small but real risk of morbidity and mortality associated with invasive colonic procedures, the routine recommendation for colon cancer screening after an episode of acute uncomplicated diverticulitis should be further evaluated.

Bottom line: The risk of malignancy after a radiologically proven episode of acute uncomplicated diverticulitis is low. In the absence of other indications, additional routine colonic evaluation may not be necessary.

Citation: Sharma PV, Eglinton T, Hider P, Frizelle F. Systematic review and meta-analysis of the role of routine colonic evaluation after radiologically confirmed acute diverticulitis. Ann Surg. 2014;259(2):263-272.

Clinical question: What is the benefit of routine colonic evaluation after an episode of acute diverticulitis?

Background: Currently accepted guidelines recommend routine colonic evaluation (colonoscopy, computed tomography (CT) colonography) after an episode of acute diverticulitis to confirm the diagnosis and exclude malignancy. Increased use of CT to confirm the diagnosis of acute diverticulitis and exclude associated complications has brought into question the recommendation for routine colonic evaluation after an episode of acute diverticulitis.

Study design: Meta-analysis.

Setting: Search of online databases and the Cochrane Library.

Synopsis: Eleven studies from seven countries included 1,970 patients who had a colonic evaluation after an episode of acute diverticulitis. The risk of finding a malignancy was 1.6%. Within this population, 1,497 patients were identified as having uncomplicated diverticulitis. Cancer was found in only five patients (proportional risk estimate 0.7%).

For the 79 patients identified as having complicated diverticulitis, the risk of finding a malignancy on subsequent screening was 10.8%.

Every systematic review is limited by the quality of the studies available for review and the differences in design and methodology of the studies. In this meta-analysis, the risk of finding cancer after an episode of uncomplicated diverticulitis appears to be low. Given the limited resources of the healthcare system and the small but real risk of morbidity and mortality associated with invasive colonic procedures, the routine recommendation for colon cancer screening after an episode of acute uncomplicated diverticulitis should be further evaluated.

Bottom line: The risk of malignancy after a radiologically proven episode of acute uncomplicated diverticulitis is low. In the absence of other indications, additional routine colonic evaluation may not be necessary.

Citation: Sharma PV, Eglinton T, Hider P, Frizelle F. Systematic review and meta-analysis of the role of routine colonic evaluation after radiologically confirmed acute diverticulitis. Ann Surg. 2014;259(2):263-272.

Clinical question: What is the benefit of routine colonic evaluation after an episode of acute diverticulitis?

Background: Currently accepted guidelines recommend routine colonic evaluation (colonoscopy, computed tomography (CT) colonography) after an episode of acute diverticulitis to confirm the diagnosis and exclude malignancy. Increased use of CT to confirm the diagnosis of acute diverticulitis and exclude associated complications has brought into question the recommendation for routine colonic evaluation after an episode of acute diverticulitis.

Study design: Meta-analysis.

Setting: Search of online databases and the Cochrane Library.

Synopsis: Eleven studies from seven countries included 1,970 patients who had a colonic evaluation after an episode of acute diverticulitis. The risk of finding a malignancy was 1.6%. Within this population, 1,497 patients were identified as having uncomplicated diverticulitis. Cancer was found in only five patients (proportional risk estimate 0.7%).

For the 79 patients identified as having complicated diverticulitis, the risk of finding a malignancy on subsequent screening was 10.8%.

Every systematic review is limited by the quality of the studies available for review and the differences in design and methodology of the studies. In this meta-analysis, the risk of finding cancer after an episode of uncomplicated diverticulitis appears to be low. Given the limited resources of the healthcare system and the small but real risk of morbidity and mortality associated with invasive colonic procedures, the routine recommendation for colon cancer screening after an episode of acute uncomplicated diverticulitis should be further evaluated.

Bottom line: The risk of malignancy after a radiologically proven episode of acute uncomplicated diverticulitis is low. In the absence of other indications, additional routine colonic evaluation may not be necessary.

Citation: Sharma PV, Eglinton T, Hider P, Frizelle F. Systematic review and meta-analysis of the role of routine colonic evaluation after radiologically confirmed acute diverticulitis. Ann Surg. 2014;259(2):263-272.

Clinical question: Does an intervention involving a facilitated physician small group result in improvement in well-being and reduction in burnout?

Background: Burnout affects nearly half of medical students, residents, and practicing physicians in the U.S.; however, very few interventions have been tested to address this problem.

Study design: Randomized controlled trial (RCT).

Setting: Department of Medicine at the Mayo Clinic, Rochester, Minn.

Synopsis: Practicing physicians were randomly assigned to facilitated, small-group intervention curriculum for one hour every two weeks (N=37) or control with unstructured, protected time for one hour every two weeks (N=37). A non-trial cohort of 350 practicing physicians was surveyed annually. This study showed a significant increase in empowerment and engagement at three months that was sustained for 12 months, and a significant decrease in high depersonalization scores was seen at both three and 12 months in the intervention group. There were no significant differences in stress, depression, quality of life, or job satisfaction.

Compared to the non-trial cohort, depersonalization, emotional exhaustion, and overall burnout decreased substantially in the intervention arm and slightly in the control arm.

Sample size was small and results may not be generalizable. Topics covered included reflection, self-awareness, and mindfulness, with a combination of community building and skill acquisition to promote connectedness and meaning in work. It is not clear which elements of the curriculum were most effective.

Bottom line: A facilitated, small-group intervention with institution-provided protected time can improve physician empowerment and engagement and reduce depersonalization, an important component of burnout.

Citation: West CP, Dyrbye LN, Rabatin JT, et al. Intervention to promote physician well-being, job satisfaction, and professionalism: a randomized clinical trial. JAMA Intern Med. 2014;174(4):527-533.

Clinical question: Does an intervention involving a facilitated physician small group result in improvement in well-being and reduction in burnout?

Background: Burnout affects nearly half of medical students, residents, and practicing physicians in the U.S.; however, very few interventions have been tested to address this problem.

Study design: Randomized controlled trial (RCT).

Setting: Department of Medicine at the Mayo Clinic, Rochester, Minn.

Synopsis: Practicing physicians were randomly assigned to facilitated, small-group intervention curriculum for one hour every two weeks (N=37) or control with unstructured, protected time for one hour every two weeks (N=37). A non-trial cohort of 350 practicing physicians was surveyed annually. This study showed a significant increase in empowerment and engagement at three months that was sustained for 12 months, and a significant decrease in high depersonalization scores was seen at both three and 12 months in the intervention group. There were no significant differences in stress, depression, quality of life, or job satisfaction.

Compared to the non-trial cohort, depersonalization, emotional exhaustion, and overall burnout decreased substantially in the intervention arm and slightly in the control arm.

Sample size was small and results may not be generalizable. Topics covered included reflection, self-awareness, and mindfulness, with a combination of community building and skill acquisition to promote connectedness and meaning in work. It is not clear which elements of the curriculum were most effective.

Bottom line: A facilitated, small-group intervention with institution-provided protected time can improve physician empowerment and engagement and reduce depersonalization, an important component of burnout.

Citation: West CP, Dyrbye LN, Rabatin JT, et al. Intervention to promote physician well-being, job satisfaction, and professionalism: a randomized clinical trial. JAMA Intern Med. 2014;174(4):527-533.

Clinical question: Does an intervention involving a facilitated physician small group result in improvement in well-being and reduction in burnout?

Background: Burnout affects nearly half of medical students, residents, and practicing physicians in the U.S.; however, very few interventions have been tested to address this problem.

Study design: Randomized controlled trial (RCT).

Setting: Department of Medicine at the Mayo Clinic, Rochester, Minn.

Synopsis: Practicing physicians were randomly assigned to facilitated, small-group intervention curriculum for one hour every two weeks (N=37) or control with unstructured, protected time for one hour every two weeks (N=37). A non-trial cohort of 350 practicing physicians was surveyed annually. This study showed a significant increase in empowerment and engagement at three months that was sustained for 12 months, and a significant decrease in high depersonalization scores was seen at both three and 12 months in the intervention group. There were no significant differences in stress, depression, quality of life, or job satisfaction.

Compared to the non-trial cohort, depersonalization, emotional exhaustion, and overall burnout decreased substantially in the intervention arm and slightly in the control arm.

Sample size was small and results may not be generalizable. Topics covered included reflection, self-awareness, and mindfulness, with a combination of community building and skill acquisition to promote connectedness and meaning in work. It is not clear which elements of the curriculum were most effective.

Bottom line: A facilitated, small-group intervention with institution-provided protected time can improve physician empowerment and engagement and reduce depersonalization, an important component of burnout.

Citation: West CP, Dyrbye LN, Rabatin JT, et al. Intervention to promote physician well-being, job satisfaction, and professionalism: a randomized clinical trial. JAMA Intern Med. 2014;174(4):527-533.

Financial pressures to reduce 30-day hospital readmissions and improve discharge processes continue to grow. The Centers for Medicare and Medicaid Services started by penalizing hospitals for up to 1% of their Medicare reimbursement via the Hospital Readmissions Reduction Program. By 2015, the program will penalize hospitals up to 3%.

This is no longer news to the hospital C-suite. A 2013 survey reported that 85% of hospital leaders had addressed the readmissions penalty in their business plan (http://content.hcpro.com/pdf/content/296905.pdf); however, the same survey revealed that only 62% of hospital leaders reported changes to clinical protocols and practices during acute care, and even fewer were providing care navigators or coaches for high-risk patients.

That’s where hospitalists can help. Through SHM’s Project BOOST, hospitalists and hospital-based care teams improve transition from hospital to home. Project BOOST also helps hospitals identify high-risk patients and target risk-specific interventions, a critical part of reducing readmissions.

Beyond the immediate financial implications, implementing programs like Project BOOST to reduce readmissions can position hospitals as leaders for better healthcare in their communities.

“I recommend Project BOOST enthusiastically and unequivocally,” says Manasi Kekan, MD, MS, FACP, medical director for Houston Methodist Hospital. “If implemented efficiently, it could result in a ‘win-win’ situation for patients, the hospital, and the healthcare providers.”

SHM is accepting applications for the 2014 Project BOOST cohort through August 30. For details and application, visit www.hospitalmedicine.org/boost.

Financial pressures to reduce 30-day hospital readmissions and improve discharge processes continue to grow. The Centers for Medicare and Medicaid Services started by penalizing hospitals for up to 1% of their Medicare reimbursement via the Hospital Readmissions Reduction Program. By 2015, the program will penalize hospitals up to 3%.

This is no longer news to the hospital C-suite. A 2013 survey reported that 85% of hospital leaders had addressed the readmissions penalty in their business plan (http://content.hcpro.com/pdf/content/296905.pdf); however, the same survey revealed that only 62% of hospital leaders reported changes to clinical protocols and practices during acute care, and even fewer were providing care navigators or coaches for high-risk patients.

That’s where hospitalists can help. Through SHM’s Project BOOST, hospitalists and hospital-based care teams improve transition from hospital to home. Project BOOST also helps hospitals identify high-risk patients and target risk-specific interventions, a critical part of reducing readmissions.

Beyond the immediate financial implications, implementing programs like Project BOOST to reduce readmissions can position hospitals as leaders for better healthcare in their communities.

“I recommend Project BOOST enthusiastically and unequivocally,” says Manasi Kekan, MD, MS, FACP, medical director for Houston Methodist Hospital. “If implemented efficiently, it could result in a ‘win-win’ situation for patients, the hospital, and the healthcare providers.”

SHM is accepting applications for the 2014 Project BOOST cohort through August 30. For details and application, visit www.hospitalmedicine.org/boost.

Financial pressures to reduce 30-day hospital readmissions and improve discharge processes continue to grow. The Centers for Medicare and Medicaid Services started by penalizing hospitals for up to 1% of their Medicare reimbursement via the Hospital Readmissions Reduction Program. By 2015, the program will penalize hospitals up to 3%.

This is no longer news to the hospital C-suite. A 2013 survey reported that 85% of hospital leaders had addressed the readmissions penalty in their business plan (http://content.hcpro.com/pdf/content/296905.pdf); however, the same survey revealed that only 62% of hospital leaders reported changes to clinical protocols and practices during acute care, and even fewer were providing care navigators or coaches for high-risk patients.

That’s where hospitalists can help. Through SHM’s Project BOOST, hospitalists and hospital-based care teams improve transition from hospital to home. Project BOOST also helps hospitals identify high-risk patients and target risk-specific interventions, a critical part of reducing readmissions.

Beyond the immediate financial implications, implementing programs like Project BOOST to reduce readmissions can position hospitals as leaders for better healthcare in their communities.

“I recommend Project BOOST enthusiastically and unequivocally,” says Manasi Kekan, MD, MS, FACP, medical director for Houston Methodist Hospital. “If implemented efficiently, it could result in a ‘win-win’ situation for patients, the hospital, and the healthcare providers.”

SHM is accepting applications for the 2014 Project BOOST cohort through August 30. For details and application, visit www.hospitalmedicine.org/boost.

With more than 44,000 hospitalists nationwide, HM continues to grow and change faster than any other medical specialty. That change can be dizzying for academic hospitalists, especially those at the beginning of their careers.

Academic Hospitalist Academy (www.academichospitalist.org), now in its sixth year, helps academic hospitalists map out a rewarding and productive career path in education and scholarship. The academy helps hospitalists:

1. Learn how to be effective teachers;
2. Understand the process necessary to create and disseminate scholarly work;
3. Become aware of the basics of promotion within an academic institution;
4. Ascertain the skills necessary to be an asset to their academic institutions;
5. Engage the skills necessary to actively participate in a mentor-mentee relationship;
6. Understand the business drivers of healthcare; and
7. Learn the basics of quality improvement and patient safety.

Academic Hospitalist Academy is an intensive, four-day program that provides a diverse array of learning formats, including didactic sessions, small-group exercises, and skill-building breakout sessions, all facilitated by leaders in the field, with small faculty-to-student ratios. The agenda also includes time for networking activities.

According to a 2013 survey of academy attendees, 100% rated it positively and 99% said they would recommend it to their colleagues.

Tuition is $2,250 for registration before Oct. 13 and $2,500 thereafter.

Academic Hospitalist Academy is co-sponsored by SHM, the Society of General Internal Medicine and the Association of Chiefs and Leaders of General Internal Medicine.

With more than 44,000 hospitalists nationwide, HM continues to grow and change faster than any other medical specialty. That change can be dizzying for academic hospitalists, especially those at the beginning of their careers.

Academic Hospitalist Academy (www.academichospitalist.org), now in its sixth year, helps academic hospitalists map out a rewarding and productive career path in education and scholarship. The academy helps hospitalists:

1. Learn how to be effective teachers;
2. Understand the process necessary to create and disseminate scholarly work;
3. Become aware of the basics of promotion within an academic institution;
4. Ascertain the skills necessary to be an asset to their academic institutions;
5. Engage the skills necessary to actively participate in a mentor-mentee relationship;
6. Understand the business drivers of healthcare; and
7. Learn the basics of quality improvement and patient safety.

Academic Hospitalist Academy is an intensive, four-day program that provides a diverse array of learning formats, including didactic sessions, small-group exercises, and skill-building breakout sessions, all facilitated by leaders in the field, with small faculty-to-student ratios. The agenda also includes time for networking activities.

According to a 2013 survey of academy attendees, 100% rated it positively and 99% said they would recommend it to their colleagues.

Tuition is $2,250 for registration before Oct. 13 and $2,500 thereafter.

Academic Hospitalist Academy is co-sponsored by SHM, the Society of General Internal Medicine and the Association of Chiefs and Leaders of General Internal Medicine.

With more than 44,000 hospitalists nationwide, HM continues to grow and change faster than any other medical specialty. That change can be dizzying for academic hospitalists, especially those at the beginning of their careers.

Academic Hospitalist Academy (www.academichospitalist.org), now in its sixth year, helps academic hospitalists map out a rewarding and productive career path in education and scholarship. The academy helps hospitalists:

1. Learn how to be effective teachers;
2. Understand the process necessary to create and disseminate scholarly work;
3. Become aware of the basics of promotion within an academic institution;
4. Ascertain the skills necessary to be an asset to their academic institutions;
5. Engage the skills necessary to actively participate in a mentor-mentee relationship;
6. Understand the business drivers of healthcare; and
7. Learn the basics of quality improvement and patient safety.

Academic Hospitalist Academy is an intensive, four-day program that provides a diverse array of learning formats, including didactic sessions, small-group exercises, and skill-building breakout sessions, all facilitated by leaders in the field, with small faculty-to-student ratios. The agenda also includes time for networking activities.

According to a 2013 survey of academy attendees, 100% rated it positively and 99% said they would recommend it to their colleagues.

Tuition is $2,250 for registration before Oct. 13 and $2,500 thereafter.

Academic Hospitalist Academy is co-sponsored by SHM, the Society of General Internal Medicine and the Association of Chiefs and Leaders of General Internal Medicine.

Safety and Brazilian Hospital

Medicine 2014

August 6-8

Rio de Janeiro, Brazil

medicinahospitalar@gmail.com

SHM’s Glycemic Control Program Informational Webinar

August 14, 2 p.m.

https://www4.gotomeeting.com/register/907579183

Palliative Medicine and Supportive Oncology 2014, The 17th International Symposium

September 18-20

Green Valley Ranch, Las Vegas

www.ccfcme.org/PM

Society of OB/GYN Hospitalists Annual Clinical Meeting OB/GYN Hospitalists: Recognition, Response, Results

September 18-20

Embassy Suites Downtown, Denver

www.societyofobgynhospitalists.com

Academic Hospitalist Academy

October 20-23

Inverness Hotel and Conference

Center, Englewood, Colo.

www.academichospitalist.org

Adult Hospital Medicine Boot Camp

October 1-5

The Westin Peachtree Plaza, Atlanta, Ga.

www.aapa.org/bootcamp

SHM Leadership Academy

November 3-6

Hilton Hawaiian Village Waikiki Beach Resort, Honolulu

www.hospitalmedicine.org/leadership

Hospital Medicine 2015

March 29-April 1, 2015

Gaylord National Resort & Convention Center, National Harbor, Md.

www.hospitalmedicine2015.org

Safety and Brazilian Hospital

Medicine 2014

August 6-8

Rio de Janeiro, Brazil

medicinahospitalar@gmail.com

SHM’s Glycemic Control Program Informational Webinar

August 14, 2 p.m.

https://www4.gotomeeting.com/register/907579183

Palliative Medicine and Supportive Oncology 2014, The 17th International Symposium

September 18-20

Green Valley Ranch, Las Vegas

www.ccfcme.org/PM

Society of OB/GYN Hospitalists Annual Clinical Meeting OB/GYN Hospitalists: Recognition, Response, Results

September 18-20

Embassy Suites Downtown, Denver

www.societyofobgynhospitalists.com

Academic Hospitalist Academy

October 20-23

Inverness Hotel and Conference

Center, Englewood, Colo.

www.academichospitalist.org

Adult Hospital Medicine Boot Camp

October 1-5

The Westin Peachtree Plaza, Atlanta, Ga.

www.aapa.org/bootcamp

SHM Leadership Academy

November 3-6

Hilton Hawaiian Village Waikiki Beach Resort, Honolulu

www.hospitalmedicine.org/leadership

Hospital Medicine 2015

March 29-April 1, 2015

Gaylord National Resort & Convention Center, National Harbor, Md.

www.hospitalmedicine2015.org

Safety and Brazilian Hospital

Medicine 2014

August 6-8

Rio de Janeiro, Brazil

medicinahospitalar@gmail.com

SHM’s Glycemic Control Program Informational Webinar

August 14, 2 p.m.

https://www4.gotomeeting.com/register/907579183

Palliative Medicine and Supportive Oncology 2014, The 17th International Symposium

September 18-20

Green Valley Ranch, Las Vegas

www.ccfcme.org/PM

Society of OB/GYN Hospitalists Annual Clinical Meeting OB/GYN Hospitalists: Recognition, Response, Results

September 18-20

Embassy Suites Downtown, Denver

www.societyofobgynhospitalists.com

Academic Hospitalist Academy

October 20-23

Inverness Hotel and Conference

Center, Englewood, Colo.

www.academichospitalist.org

Adult Hospital Medicine Boot Camp

October 1-5

The Westin Peachtree Plaza, Atlanta, Ga.

www.aapa.org/bootcamp

SHM Leadership Academy

November 3-6

Hilton Hawaiian Village Waikiki Beach Resort, Honolulu

www.hospitalmedicine.org/leadership

Hospital Medicine 2015

March 29-April 1, 2015

Gaylord National Resort & Convention Center, National Harbor, Md.

www.hospitalmedicine2015.org

Illustrative case
A healthy neonate is born through clear amniotic fluid with no meconium. She is vigorous and has no major congenital anomalies. Does she need oronasopharyngeal suctioning?

No, she does not need suctioning. Although it is still standard practice to perform oronasopharyngeal suctioning with a bulb syringe immediately after delivery, multiple studies have found no benefit to routine suctioning.^2-7 Guidelines from the Neonatal Resuscitation Program (NRP) and other organizations recommend against the practice, even for neonates born through meconium-stained amniotic fluid.^8,9 Suctioning is done because some clinicians believe it reduces the risk of aspiration, especially if there is meconium, and to stimulate breathing, but the evidence suggests that suctioning can stimulate the vagus nerve, which can lead to bradycardia.² Studies that compared babies who did and didn’t receive suctioning found that those who received it had lower Apgar scores and oxygen saturation levels.^2-4

Wiping the neonate’s mouth and nose with a towel is an alternative to suctioning, but until now no trials have compared the outcomes of these 2 methods. Kelleher et al¹ conducted an equivalency trial to determine if wiping the mouth and nose is as effective as oronasopharyngeal suctioning.

STUDY SUMMARY: No difference in breathing 
after wiping or suctioning

Kelleher et al¹ studied neonates born after at least 35 weeks gestation, excluding those who had major congenital anomalies or were non-vigorous (depressed muscle tone or respiration, heart rate <100 beats/min, or both) and born into meconium-stained amniotic fluid, as well as those whom they anticipated would need advanced resuscitation. Neonates were randomly assigned to receive either oronasopharyngeal suctioning with a bulb syringe or wiping of the face and mouth with a towel, starting immediately after the umbilical cord was cut and lasting as long as needed while in the delivery room. The primary outcome was the mean respiratory rate in the first 24 hours after birth. The predefined range of clinical equivalence between the 2 groups was a respiratory rate within 4 breaths/min.

Of 506 neonates randomized, 15 were excluded because they were not vigorous and had meconium-stained fluid, and 3 were excluded when their parents withdrew consent. Baseline characteristics for the 2 groups—including maternal age, presence of chronic medical conditions, and body mass index; vaginal vs cesarean delivery; umbilical artery pH; and neonatal sex, ethnic origin, and birth weight—were similar.

In the first 24 hours after birth, the average respiratory rate in the wiping group was 51 breaths/min (standard deviation [SD] ± 8) vs 50 breaths/min (SD ± 6) in the suctioning group. There was no difference in respiratory rates between the 2 groups at 1, 8, or 16 hours after birth. There was also no difference between the 2 groups in Apgar scores or need for advanced resuscitation. More neonates in the wiping group than in the suctioning group were admitted to the neonatal intensive care unit (45 of 246 [18%] vs 30 of 242 [12%]; P=.07), but the study was not powered to assess this outcome.

WHAT'S NEW: Wiping is as effective as suctioning,
 but there are no adverse effects

This study gives us evidence that wiping the face, mouth, and nose is equivalent to suctioning newborns at delivery, and it supports the NRP recommendation against routine suctioning in vigorous neonates born at term. Wiping avoids the potential adverse effects on the respiratory mucosa, bradycardia, and lower Apgar scores associated with suctioning via bulb syringes.

CAVEATS: Wiping is not best 
if a neonate’s airway is obstructed

This study looked only at neonates born after 35 weeks’ gestation who did not have meconium-stained amniotic fluid or congenital abnormalities. Also, NRP guidelines do recommend clearing the airways with a bulb syringe or suction catheter if airway obstruction is evident or positive-pressure ventilation is required.⁸

Another caveat ... In this study,¹ there were 98 treatment crossovers: 64 of the 246 neonates in the wiping group received suctioning, and 34 of the 242 neonates in the suctioning group received wiping. However, this was not likely to change the study’s overall conclusion because a per-treatment analysis also found that wiping and suctioning were equivalent.

CHALLENGES TO IMPLEMENTATION: “We’ve always done it this way”
Practice patterns in a delivery room can be difficult to change. As we work on improving our delivery room environment and changing ingrained habits, the evidence from this study should help support the use of wiping in place of suctioning. The transition from suctioning to wiping also would be facilitated by having easily accessible towels designated for wiping.

Acknowledgement
The PURLs Surveillance System was supported in part by Grant Number UL1RR024999 from the National Center For Research Resources, a Clinical Translational Science Award to the University of Chicago. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center For Research Resources or the National Institutes of Health.

PURL METHODOLOGY

…..

Illustrative case
A healthy neonate is born through clear amniotic fluid with no meconium. She is vigorous and has no major congenital anomalies. Does she need oronasopharyngeal suctioning?

No, she does not need suctioning. Although it is still standard practice to perform oronasopharyngeal suctioning with a bulb syringe immediately after delivery, multiple studies have found no benefit to routine suctioning.^2-7 Guidelines from the Neonatal Resuscitation Program (NRP) and other organizations recommend against the practice, even for neonates born through meconium-stained amniotic fluid.^8,9 Suctioning is done because some clinicians believe it reduces the risk of aspiration, especially if there is meconium, and to stimulate breathing, but the evidence suggests that suctioning can stimulate the vagus nerve, which can lead to bradycardia.² Studies that compared babies who did and didn’t receive suctioning found that those who received it had lower Apgar scores and oxygen saturation levels.^2-4

Wiping the neonate’s mouth and nose with a towel is an alternative to suctioning, but until now no trials have compared the outcomes of these 2 methods. Kelleher et al¹ conducted an equivalency trial to determine if wiping the mouth and nose is as effective as oronasopharyngeal suctioning.

STUDY SUMMARY: No difference in breathing 
after wiping or suctioning

Kelleher et al¹ studied neonates born after at least 35 weeks gestation, excluding those who had major congenital anomalies or were non-vigorous (depressed muscle tone or respiration, heart rate <100 beats/min, or both) and born into meconium-stained amniotic fluid, as well as those whom they anticipated would need advanced resuscitation. Neonates were randomly assigned to receive either oronasopharyngeal suctioning with a bulb syringe or wiping of the face and mouth with a towel, starting immediately after the umbilical cord was cut and lasting as long as needed while in the delivery room. The primary outcome was the mean respiratory rate in the first 24 hours after birth. The predefined range of clinical equivalence between the 2 groups was a respiratory rate within 4 breaths/min.

Of 506 neonates randomized, 15 were excluded because they were not vigorous and had meconium-stained fluid, and 3 were excluded when their parents withdrew consent. Baseline characteristics for the 2 groups—including maternal age, presence of chronic medical conditions, and body mass index; vaginal vs cesarean delivery; umbilical artery pH; and neonatal sex, ethnic origin, and birth weight—were similar.

In the first 24 hours after birth, the average respiratory rate in the wiping group was 51 breaths/min (standard deviation [SD] ± 8) vs 50 breaths/min (SD ± 6) in the suctioning group. There was no difference in respiratory rates between the 2 groups at 1, 8, or 16 hours after birth. There was also no difference between the 2 groups in Apgar scores or need for advanced resuscitation. More neonates in the wiping group than in the suctioning group were admitted to the neonatal intensive care unit (45 of 246 [18%] vs 30 of 242 [12%]; P=.07), but the study was not powered to assess this outcome.

WHAT'S NEW: Wiping is as effective as suctioning,
 but there are no adverse effects

This study gives us evidence that wiping the face, mouth, and nose is equivalent to suctioning newborns at delivery, and it supports the NRP recommendation against routine suctioning in vigorous neonates born at term. Wiping avoids the potential adverse effects on the respiratory mucosa, bradycardia, and lower Apgar scores associated with suctioning via bulb syringes.

CAVEATS: Wiping is not best 
if a neonate’s airway is obstructed

This study looked only at neonates born after 35 weeks’ gestation who did not have meconium-stained amniotic fluid or congenital abnormalities. Also, NRP guidelines do recommend clearing the airways with a bulb syringe or suction catheter if airway obstruction is evident or positive-pressure ventilation is required.⁸

Another caveat ... In this study,¹ there were 98 treatment crossovers: 64 of the 246 neonates in the wiping group received suctioning, and 34 of the 242 neonates in the suctioning group received wiping. However, this was not likely to change the study’s overall conclusion because a per-treatment analysis also found that wiping and suctioning were equivalent.

CHALLENGES TO IMPLEMENTATION: “We’ve always done it this way”
Practice patterns in a delivery room can be difficult to change. As we work on improving our delivery room environment and changing ingrained habits, the evidence from this study should help support the use of wiping in place of suctioning. The transition from suctioning to wiping also would be facilitated by having easily accessible towels designated for wiping.

Acknowledgement
The PURLs Surveillance System was supported in part by Grant Number UL1RR024999 from the National Center For Research Resources, a Clinical Translational Science Award to the University of Chicago. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center For Research Resources or the National Institutes of Health.

PURL METHODOLOGY

…..

Illustrative case
A healthy neonate is born through clear amniotic fluid with no meconium. She is vigorous and has no major congenital anomalies. Does she need oronasopharyngeal suctioning?

No, she does not need suctioning. Although it is still standard practice to perform oronasopharyngeal suctioning with a bulb syringe immediately after delivery, multiple studies have found no benefit to routine suctioning.^2-7 Guidelines from the Neonatal Resuscitation Program (NRP) and other organizations recommend against the practice, even for neonates born through meconium-stained amniotic fluid.^8,9 Suctioning is done because some clinicians believe it reduces the risk of aspiration, especially if there is meconium, and to stimulate breathing, but the evidence suggests that suctioning can stimulate the vagus nerve, which can lead to bradycardia.² Studies that compared babies who did and didn’t receive suctioning found that those who received it had lower Apgar scores and oxygen saturation levels.^2-4

Wiping the neonate’s mouth and nose with a towel is an alternative to suctioning, but until now no trials have compared the outcomes of these 2 methods. Kelleher et al¹ conducted an equivalency trial to determine if wiping the mouth and nose is as effective as oronasopharyngeal suctioning.

STUDY SUMMARY: No difference in breathing 
after wiping or suctioning

Kelleher et al¹ studied neonates born after at least 35 weeks gestation, excluding those who had major congenital anomalies or were non-vigorous (depressed muscle tone or respiration, heart rate <100 beats/min, or both) and born into meconium-stained amniotic fluid, as well as those whom they anticipated would need advanced resuscitation. Neonates were randomly assigned to receive either oronasopharyngeal suctioning with a bulb syringe or wiping of the face and mouth with a towel, starting immediately after the umbilical cord was cut and lasting as long as needed while in the delivery room. The primary outcome was the mean respiratory rate in the first 24 hours after birth. The predefined range of clinical equivalence between the 2 groups was a respiratory rate within 4 breaths/min.

Of 506 neonates randomized, 15 were excluded because they were not vigorous and had meconium-stained fluid, and 3 were excluded when their parents withdrew consent. Baseline characteristics for the 2 groups—including maternal age, presence of chronic medical conditions, and body mass index; vaginal vs cesarean delivery; umbilical artery pH; and neonatal sex, ethnic origin, and birth weight—were similar.

In the first 24 hours after birth, the average respiratory rate in the wiping group was 51 breaths/min (standard deviation [SD] ± 8) vs 50 breaths/min (SD ± 6) in the suctioning group. There was no difference in respiratory rates between the 2 groups at 1, 8, or 16 hours after birth. There was also no difference between the 2 groups in Apgar scores or need for advanced resuscitation. More neonates in the wiping group than in the suctioning group were admitted to the neonatal intensive care unit (45 of 246 [18%] vs 30 of 242 [12%]; P=.07), but the study was not powered to assess this outcome.

WHAT'S NEW: Wiping is as effective as suctioning,
 but there are no adverse effects

This study gives us evidence that wiping the face, mouth, and nose is equivalent to suctioning newborns at delivery, and it supports the NRP recommendation against routine suctioning in vigorous neonates born at term. Wiping avoids the potential adverse effects on the respiratory mucosa, bradycardia, and lower Apgar scores associated with suctioning via bulb syringes.

CAVEATS: Wiping is not best 
if a neonate’s airway is obstructed

This study looked only at neonates born after 35 weeks’ gestation who did not have meconium-stained amniotic fluid or congenital abnormalities. Also, NRP guidelines do recommend clearing the airways with a bulb syringe or suction catheter if airway obstruction is evident or positive-pressure ventilation is required.⁸

Another caveat ... In this study,¹ there were 98 treatment crossovers: 64 of the 246 neonates in the wiping group received suctioning, and 34 of the 242 neonates in the suctioning group received wiping. However, this was not likely to change the study’s overall conclusion because a per-treatment analysis also found that wiping and suctioning were equivalent.

CHALLENGES TO IMPLEMENTATION: “We’ve always done it this way”
Practice patterns in a delivery room can be difficult to change. As we work on improving our delivery room environment and changing ingrained habits, the evidence from this study should help support the use of wiping in place of suctioning. The transition from suctioning to wiping also would be facilitated by having easily accessible towels designated for wiping.

Acknowledgement
The PURLs Surveillance System was supported in part by Grant Number UL1RR024999 from the National Center For Research Resources, a Clinical Translational Science Award to the University of Chicago. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center For Research Resources or the National Institutes of Health.

PURL METHODOLOGY

…..