Breast Cancer

SAN ANTONIO – Two large phase III randomized trials comparing anastrozole and tamoxifen for prevention of disease recurrence in postmenopausal women with ductal carcinoma in situ were presented at the San Antonio Breast Cancer Symposium.

In an interview, Dr. Anthony Howell, professor of medical oncology at the University of Manchester, England, provides the key take-home lessons from the NSABP B-35 and IBIS-II DCIS trials.

bjancin@frontlinemedcom.com

SAN ANTONIO – Two large phase III randomized trials comparing anastrozole and tamoxifen for prevention of disease recurrence in postmenopausal women with ductal carcinoma in situ were presented at the San Antonio Breast Cancer Symposium.

In an interview, Dr. Anthony Howell, professor of medical oncology at the University of Manchester, England, provides the key take-home lessons from the NSABP B-35 and IBIS-II DCIS trials.

bjancin@frontlinemedcom.com

SAN ANTONIO – Two large phase III randomized trials comparing anastrozole and tamoxifen for prevention of disease recurrence in postmenopausal women with ductal carcinoma in situ were presented at the San Antonio Breast Cancer Symposium.

In an interview, Dr. Anthony Howell, professor of medical oncology at the University of Manchester, England, provides the key take-home lessons from the NSABP B-35 and IBIS-II DCIS trials.

bjancin@frontlinemedcom.com

SAN ANTONIO – Prophylactic beta-blockade with bisoprolol during adjuvant trastuzumab therapy for HER2-positive breast cancer prevented trastuzumab-induced decline in left ventricular ejection fraction in a randomized trial.

In an interview at the San Antonio Breast Cancer Symposium, Dr. Edie Pituskin of the University of Alberta, Edmonton, explained why the double-blind, placebo-controlled MANTICORE trial may change clinical practice.

bjancin@frontlinemedcom.com

SAN ANTONIO – Prophylactic beta-blockade with bisoprolol during adjuvant trastuzumab therapy for HER2-positive breast cancer prevented trastuzumab-induced decline in left ventricular ejection fraction in a randomized trial.

In an interview at the San Antonio Breast Cancer Symposium, Dr. Edie Pituskin of the University of Alberta, Edmonton, explained why the double-blind, placebo-controlled MANTICORE trial may change clinical practice.

bjancin@frontlinemedcom.com

SAN ANTONIO – Prophylactic beta-blockade with bisoprolol during adjuvant trastuzumab therapy for HER2-positive breast cancer prevented trastuzumab-induced decline in left ventricular ejection fraction in a randomized trial.

In an interview at the San Antonio Breast Cancer Symposium, Dr. Edie Pituskin of the University of Alberta, Edmonton, explained why the double-blind, placebo-controlled MANTICORE trial may change clinical practice.

bjancin@frontlinemedcom.com

SAN ANTONIO – Mutations of the estrogen receptor 1 (ESR1) gene are more common than previously thought in women with advanced estrogen receptor–positive breast cancer and are associated with poorer survival. In an interview at the San Antonio Breast Cancer Symposium, Dr. Sarat Chandarlapaty of Memorial Sloan Kettering Cancer Center, New York, discusses a mutational analysis of cell-free DNA in blood samples from the BOLERO-2 trial and how the findings may help refine therapeutic strategies.

SAN ANTONIO – Mutations of the estrogen receptor 1 (ESR1) gene are more common than previously thought in women with advanced estrogen receptor–positive breast cancer and are associated with poorer survival. In an interview at the San Antonio Breast Cancer Symposium, Dr. Sarat Chandarlapaty of Memorial Sloan Kettering Cancer Center, New York, discusses a mutational analysis of cell-free DNA in blood samples from the BOLERO-2 trial and how the findings may help refine therapeutic strategies.

SAN ANTONIO – Mutations of the estrogen receptor 1 (ESR1) gene are more common than previously thought in women with advanced estrogen receptor–positive breast cancer and are associated with poorer survival. In an interview at the San Antonio Breast Cancer Symposium, Dr. Sarat Chandarlapaty of Memorial Sloan Kettering Cancer Center, New York, discusses a mutational analysis of cell-free DNA in blood samples from the BOLERO-2 trial and how the findings may help refine therapeutic strategies.

SAN ANTONIO – Premenopausal women with luminal A tumors did not derive benefit from adjuvant cyclophosphamide-based chemotherapy.

In an interview, Dr. Torsten Nielsen, professor of pathology at the University of British Columbia in Vancouver, discusses the prospective-retrospective study and whether its findings will prompt patients with these tumors and their physicians to skip chemotherapy.

SAN ANTONIO – Premenopausal women with luminal A tumors did not derive benefit from adjuvant cyclophosphamide-based chemotherapy.

In an interview, Dr. Torsten Nielsen, professor of pathology at the University of British Columbia in Vancouver, discusses the prospective-retrospective study and whether its findings will prompt patients with these tumors and their physicians to skip chemotherapy.

SAN ANTONIO – Premenopausal women with luminal A tumors did not derive benefit from adjuvant cyclophosphamide-based chemotherapy.

In an interview, Dr. Torsten Nielsen, professor of pathology at the University of British Columbia in Vancouver, discusses the prospective-retrospective study and whether its findings will prompt patients with these tumors and their physicians to skip chemotherapy.

SAN ANTONIO – Patients with estrogen receptor–positive breast cancers who had up-regulation of the APOBEC3B enzyme – a DNA-mutating enzyme – had a shorter time to progression on tamoxifen. In addition, suppressing levels of the enzyme in a preclinical model reduced tamoxifen resistance. In an interview, Reuben Harris, Ph.D., professor in the department of biochemistry, molecular biology, and biophysics at the University of Minnesota, Minneapolis, discussed the study’s findings and what they mean for the conduct of clinical trials and for future research.

SAN ANTONIO – Patients with estrogen receptor–positive breast cancers who had up-regulation of the APOBEC3B enzyme – a DNA-mutating enzyme – had a shorter time to progression on tamoxifen. In addition, suppressing levels of the enzyme in a preclinical model reduced tamoxifen resistance. In an interview, Reuben Harris, Ph.D., professor in the department of biochemistry, molecular biology, and biophysics at the University of Minnesota, Minneapolis, discussed the study’s findings and what they mean for the conduct of clinical trials and for future research.

SAN ANTONIO – Patients with estrogen receptor–positive breast cancers who had up-regulation of the APOBEC3B enzyme – a DNA-mutating enzyme – had a shorter time to progression on tamoxifen. In addition, suppressing levels of the enzyme in a preclinical model reduced tamoxifen resistance. In an interview, Reuben Harris, Ph.D., professor in the department of biochemistry, molecular biology, and biophysics at the University of Minnesota, Minneapolis, discussed the study’s findings and what they mean for the conduct of clinical trials and for future research.

SAN ANTONIO – Mastectomy with reconstruction is the outlier in terms of complication rates and cost among options for local therapy for early breast cancer, according to a large observational study presented at the San Antonio Breast Cancer Symposium.

Complication rates during the first 2 years after diagnosis were roughly twice as high for mastectomy plus reconstruction, compared with lumpectomy with whole breast irradiation. Moreover, average total procedural and complication costs were $23,000 greater for women aged 65 years or younger who opted for mastectomy plus reconstruction than for those who chose lumpectomy plus whole breast irradiation. These fresh insights into the trade-offs involved in local treatment options should prove useful in oncologists’ discussions with newly diagnosed patients, as well as for payers, as Dr. Benjamin D. Smith of University of Texas M.D. Anderson Cancer Center, Houston, explains in an interview.

bjancin@frontlinemedcom.com

SAN ANTONIO – Mastectomy with reconstruction is the outlier in terms of complication rates and cost among options for local therapy for early breast cancer, according to a large observational study presented at the San Antonio Breast Cancer Symposium.

Complication rates during the first 2 years after diagnosis were roughly twice as high for mastectomy plus reconstruction, compared with lumpectomy with whole breast irradiation. Moreover, average total procedural and complication costs were $23,000 greater for women aged 65 years or younger who opted for mastectomy plus reconstruction than for those who chose lumpectomy plus whole breast irradiation. These fresh insights into the trade-offs involved in local treatment options should prove useful in oncologists’ discussions with newly diagnosed patients, as well as for payers, as Dr. Benjamin D. Smith of University of Texas M.D. Anderson Cancer Center, Houston, explains in an interview.

bjancin@frontlinemedcom.com

SAN ANTONIO – Mastectomy with reconstruction is the outlier in terms of complication rates and cost among options for local therapy for early breast cancer, according to a large observational study presented at the San Antonio Breast Cancer Symposium.

Complication rates during the first 2 years after diagnosis were roughly twice as high for mastectomy plus reconstruction, compared with lumpectomy with whole breast irradiation. Moreover, average total procedural and complication costs were $23,000 greater for women aged 65 years or younger who opted for mastectomy plus reconstruction than for those who chose lumpectomy plus whole breast irradiation. These fresh insights into the trade-offs involved in local treatment options should prove useful in oncologists’ discussions with newly diagnosed patients, as well as for payers, as Dr. Benjamin D. Smith of University of Texas M.D. Anderson Cancer Center, Houston, explains in an interview.

bjancin@frontlinemedcom.com

SAN ANTONIO – Adding weekly carboplatin to 18 weeks of anthracycline/taxane-based neoadjuvant chemotherapy markedly improved disease-free survival in patients with triple-negative breast cancer, according to updated results from the GeparSixto trial presented at the San Antonio Breast Cancer Symposium.

Dr. Gunter von Minckwitz, president of the German Breast Group, explains in an interview that the nearly 50% reduction in the risk of disease relapse at 3 years seen in the phase II trial has converted him and his coinvestigators to routine use of add-on carboplatin in triple-negative breast cancer patients on neoadjuvant chemotherapy.

bjancin@frontlinemedcom.com

SAN ANTONIO – Adding weekly carboplatin to 18 weeks of anthracycline/taxane-based neoadjuvant chemotherapy markedly improved disease-free survival in patients with triple-negative breast cancer, according to updated results from the GeparSixto trial presented at the San Antonio Breast Cancer Symposium.

Dr. Gunter von Minckwitz, president of the German Breast Group, explains in an interview that the nearly 50% reduction in the risk of disease relapse at 3 years seen in the phase II trial has converted him and his coinvestigators to routine use of add-on carboplatin in triple-negative breast cancer patients on neoadjuvant chemotherapy.

bjancin@frontlinemedcom.com

SAN ANTONIO – Adding weekly carboplatin to 18 weeks of anthracycline/taxane-based neoadjuvant chemotherapy markedly improved disease-free survival in patients with triple-negative breast cancer, according to updated results from the GeparSixto trial presented at the San Antonio Breast Cancer Symposium.

Dr. Gunter von Minckwitz, president of the German Breast Group, explains in an interview that the nearly 50% reduction in the risk of disease relapse at 3 years seen in the phase II trial has converted him and his coinvestigators to routine use of add-on carboplatin in triple-negative breast cancer patients on neoadjuvant chemotherapy.

bjancin@frontlinemedcom.com

SAN ANTONIO – Adjuvant capecitabine improved both disease-free and overall survival in women with HER2-negative breast cancer who had residual disease after neoadjuvant chemotherapy. In an interview, Dr. Masakazu Toi, a professor at Kyoto University Hospital, and founder and senior director of the Japan Breast Cancer Research Group, discusses the phase III CREATE-X trial and its implications for clinical care.

SAN ANTONIO – Adjuvant capecitabine improved both disease-free and overall survival in women with HER2-negative breast cancer who had residual disease after neoadjuvant chemotherapy. In an interview, Dr. Masakazu Toi, a professor at Kyoto University Hospital, and founder and senior director of the Japan Breast Cancer Research Group, discusses the phase III CREATE-X trial and its implications for clinical care.

SAN ANTONIO – Adjuvant capecitabine improved both disease-free and overall survival in women with HER2-negative breast cancer who had residual disease after neoadjuvant chemotherapy. In an interview, Dr. Masakazu Toi, a professor at Kyoto University Hospital, and founder and senior director of the Japan Breast Cancer Research Group, discusses the phase III CREATE-X trial and its implications for clinical care.

SAN ANTONIO – Adding denosumab to adjuvant aromatase inhibitor therapy, not only reduced risk of fracture, but also improved disease-free survival for postmenopausal patients with early-stage, hormone receptor–positive breast cancer, according to results presented at the San Antonio Breast Cancer Symposium.

In an interview, Dr. Michael Gnant, professor of surgery at the Medical University of Vienna, discusses the phase III ABCSG-18 clinical trial, and why he will now be prescribing denosumab to HR-positive breast cancer patients who are receiving adjuvant aromatase inhibitor therapy, regardless of their bone health status.

bjancin@frontlinemedcom.com

SAN ANTONIO – Adding denosumab to adjuvant aromatase inhibitor therapy, not only reduced risk of fracture, but also improved disease-free survival for postmenopausal patients with early-stage, hormone receptor–positive breast cancer, according to results presented at the San Antonio Breast Cancer Symposium.

In an interview, Dr. Michael Gnant, professor of surgery at the Medical University of Vienna, discusses the phase III ABCSG-18 clinical trial, and why he will now be prescribing denosumab to HR-positive breast cancer patients who are receiving adjuvant aromatase inhibitor therapy, regardless of their bone health status.

bjancin@frontlinemedcom.com

SAN ANTONIO – Adding denosumab to adjuvant aromatase inhibitor therapy, not only reduced risk of fracture, but also improved disease-free survival for postmenopausal patients with early-stage, hormone receptor–positive breast cancer, according to results presented at the San Antonio Breast Cancer Symposium.

In an interview, Dr. Michael Gnant, professor of surgery at the Medical University of Vienna, discusses the phase III ABCSG-18 clinical trial, and why he will now be prescribing denosumab to HR-positive breast cancer patients who are receiving adjuvant aromatase inhibitor therapy, regardless of their bone health status.

bjancin@frontlinemedcom.com