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Pembrolizumab bests chemo in PD-L1-positive esophageal cancer
SAN FRANCISCO – In KEYNOTE-181, second-line pembrolizumab reduced risk of death by 31% relative to chemotherapy among patients whose esophageal...
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Age may dictate benefit of andecaliximab in gastric cancer
SAN FRANCISCO – Older adults appeared to derive both progression-free and overall survival benefit in the GAMMA-1 trial, which tested addition of...
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COLOPEC: Adjuvant HIPEC for high-risk colon cancer disappoints
SAN FRANCISCO – Adding adjuvant oxaliplatin HIPEC to routine adjuvant systemic chemotherapy did not improve survival without peritoneal recurrence...
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Young women opt for mastectomy even when neoadjuvant chemo works well
SAN ANTONIO – Although neoadjuvant chemotherapy doubled the proportion of women eligible for breast-conserving surgery, about 40% chose mastectomy...
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Older breast cancer patients given adjuvant chemo live longer
SAN ANTONIO – Overall survival is better in breast cancer patients aged 65 years and older who receive adjuvant chemotherapy, although patients...
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QOL is poorer for young women after mastectomy than BCS
SAN ANTONIO – A cohort study of 560 breast cancer survivors aged 40 or younger at diagnosis finds that breast satisfaction and several domains of...
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Oxybutynin rapidly quells hot flashes
SAN ANTONIO - Oxybutynin reduced hot flash scores by at least two-thirds, improved measures of quality of life, and was safe and well tolerated in...
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Partial- and whole-breast irradiation very close in efficacy
SAN ANTONIO – A phase 3 trial among women who had undergone lumpectomy could not refute the hypothesis that PBI was inferior to WBI, but the...
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AMAROS: Radiation has edge for axillary treatment
SAN ANTONIO – In patients with a positive sentinel node, axillary radiation has similar efficacy to axillary lymph node dissection and less...
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Oxybutynin nets dramatic reduction in hot flashes
SAN ANTONIO – The 6-week reduction in a hot flash score capturing both frequency and severity was about 30% with placebo, 65% with oxybutynin 2.5...
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Extent of breast surgery is tied to quality of life among young breast cancer survivors
SAN ANTONIO – Younger breast cancer patients who undergo unilateral or bilateral mastectomy report lower breast satisfaction and poorer...
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pCR may obviate need for adjuvant chemotherapy
SAN ANTONIO – A meta-analysis finds no added event-free survival benefit from adjuvant chemotherapy among the 21.1% of patients who achieved a pCR...
Video
RT of lymph nodes as good as dissection for the long-term
SAN ANTONIO – Both axillary RT and axillary lymph node dissection provide excellent, comparable locoregional control in patients with early-stage...
Video
Nothing to gain from chemo after pCR achieved
SAN ANTONIO - The only thing women with localized breast cancer who achieve a pCR after neoadjuvant chemo may gain from further chemo from...
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Small absolute difference between partial and whole breast irradiation
SAN ANTONIO – A phase 3 trial was unable to rule out the possibility that, after lumpectomy, partial breast irradiation is inferior to whole...